Document Detail


Correlation of hepatic venous pressure gradient with variceal bleeding, size of esophageal varices, etiology, ascites and degree of liver dysfunction in cirrhosis of liver.
MedLine Citation:
PMID:  19696990     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An elevated hepatic venous pressure gradient (HVPG) has been associated with risk of variceal bleeding, and outcome and survival after variceal bleeding. In this pilot study, we measured HVPG in 40 patients with liver cirrhosis and studied its relationship with etiology of liver disease, esophageal variceal size, history of variceal bleeding or ascites, biochemical liver tests and Child-Pugh class. There was no procedurerelated complication. The mean (SD) HVPG was similar in patients who had history of variceal bleeding as compared to those who did not (15.4 [2.8] mmHg vs. 13.9 [2.7] mmHg, p=0.1); HVPG had no significant association with etiology of cirrhosis (p=0.4). HVPG levels were significantly higher in patients with larger esophageal varices (grade III/IV vs. I/II: 15.2 [2.7] mmHg vs.13.1 [2.8] mmHg, p=0.04), poorer Child-Pugh class (B or C versus A), and presence of ascites (p=0.04). Thus, HVPG correlated with variceal size, Child-Pugh class, and presence of ascites, but not with variceal bleeding status.
Authors:
Ghulam Mohamad Gulzar; Showkat Ali Zargar; Sheikh Jalal; Mohamad Sultan Alaie; Gul Javid; Pawan Kumar Suri; Nisar Ahmad Shah; Bilal-Ul-Rehman; Mohamad Shafi Hakeem; Abid Shoukat; Gulzar Ahmad Dar
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-08-21
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  28     ISSN:  0975-0711     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-08-21     Completed Date:  2010-03-04     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  59-61     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, 190 011, India.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Ascites / etiology*,  physiopathology
Catheterization, Central Venous
Endoscopy, Gastrointestinal
Female
Gastrointestinal Hemorrhage / etiology,  pathology,  physiopathology*
Humans
Liver Cirrhosis / complications*,  physiopathology
Liver Failure / complications,  diagnosis,  physiopathology*
Liver Function Tests
Male
Middle Aged
Pilot Projects
Prognosis
Retrospective Studies
Severity of Illness Index
Venous Pressure / physiology*
Young Adult

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