Document Detail

Correlation of haemoglobin-acrylamide adducts with airborne exposure: an occupational survey.
MedLine Citation:
PMID:  16257145     Owner:  NLM     Status:  MEDLINE    
This paper reports an occupational hygiene survey of exposure to acrylamide comparing acrylamide haemoglobin adduct measurements with personal air monitoring and glove liner analysis. The air monitoring data showed that exposure to acrylamide was well-controlled with all samples below the UK maximum exposure limit (MEL) of 300 microg/m(3) with mean exposure about one tenth of the MEL. Each worker provided two blood samples approximately 3 months apart. These samples were well correlated (r=0.61) with a slope of 0.74, indicating that exposure was reasonably constant. Mean personal airborne acrylamide levels and mean acrylamide haemoglobin adduct levels were well correlated (r=0.72, N=46) and using the calculated linear correlation, exposure at the MEL would be expected to give rise to a haemoglobin adduct level of 1,550 pmol/g globin. Smoking status did not affect the correlation. There was also a correlation between levels of acrylamide detected on gloves and haemoglobin adduct levels. A combined regression model between haemoglobin adducts, airborne acrylamide and acrylamide glove contamination was significant for both airborne acrylamide and gloves with a regression coefficient of 0.89. The study showed that haemoglobin adduct level was a good biomarker of acrylamide exposure which correlated to both inhaled and potentially skin absorbed acrylamide estimates. There was excellent discrimination between well-controlled occupational levels and environmental levels from diet and smoking, allowing haemoglobin adduct measurement to be used to determine even low level exposures. Due to the complexity of the current methodology, new techniques would be useful in making haemoglobin adducts more widely applicable.
Kate Jones; Sarah Garfitt; Vicky Emms; Nick Warren; John Cocker; Peter Farmer
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Publication Detail:
Type:  Journal Article     Date:  2005-10-27
Journal Detail:
Title:  Toxicology letters     Volume:  162     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-02-20     Completed Date:  2006-04-14     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  174-80     Citation Subset:  IM    
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MeSH Terms
Acrylamide / analysis,  metabolism*
Air Pollutants, Occupational / analysis,  metabolism*
Biological Markers
Environmental Monitoring
Gloves, Protective
Hemoglobins / metabolism*
Inhalation Exposure / analysis
Occupational Exposure / analysis*
Protein Binding
Skin Absorption
Grant Support
G0100873//Medical Research Council
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Biological Markers; 0/Hemoglobins; 20R035KLCI/Acrylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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