Document Detail


Correlation of force-length area with oxygen consumption in ferret papillary muscle.
MedLine Citation:
PMID:  3621495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ventricular systolic pressure-volume area correlates well with myocardial oxygen consumption. However, in isolated muscle preparations, there are experimental data based on both mechanical and energetic measurements that suggest that the pressure-volume area concept may not obtain. In the present study, force-length area, the analog of pressure-volume area for a linear muscle, was examined in the ferret papillary muscle preparation under a wide range of loading conditions. There were two major findings: first, force-length area is closely correlated with oxygen consumption (r = 0.94-0.98); this correlation is better than those for such other indexes as peak force and force-time integral. Furthermore, this relation of oxygen consumption with force-length area is independent of the mode of contraction (isometric or shortening), while the relations with the other indexes are not. Second, quick release imposed after end-systole during isometric contraction was found to curtail oxygen consumption. The first finding, the optimal correlation of force-length area with oxygen consumption, suggests both that the correlation of pressure-volume area with oxygen consumption on the ventricular level arises from a basic property of cardiac muscle and that force-length area may be the best mechanical index to use in calculating regional oxygen consumption for a ventricular segment. The second finding, however, suggests that the time-varying elastance model, on which the concepts of pressure-volume area and force-length area are based, may not provide a complete description of the mechanical basis of cardiac muscle energetics, especially during the isometric contraction.
Authors:
R Hisano; G Cooper
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation research     Volume:  61     ISSN:  0009-7330     ISO Abbreviation:  Circ. Res.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-13     Completed Date:  1987-10-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  318-28     Citation Subset:  IM; S    
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MeSH Terms
Descriptor/Qualifier:
Animals
Biomechanics
Ferrets
Male
Oxygen Consumption*
Papillary Muscles / anatomy & histology,  metabolism,  physiology*
Systole
Time Factors
Grant Support
ID/Acronym/Agency:
HL29718/HL/NHLBI NIH HHS; HL37196/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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