| CORRELATION OF THE FINE STRUCTURE OF THE GASTRIC PARIETAL CELL (DOG) WITH FUNCTIONAL ACTIVITY OF THE STOMACH. | |
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MedLine Citation:
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PMID: 19866597 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The fine structure of the parietal (oxyntic) cell in the gastric glands (corpus of the stomach) of the dog was examined under conditions of active gastric acid secretion and compared with cellular structure in the non-acid-secretory (basal) state. Animals, in both acute and chronic experiments, were equipped with gastric fistulae so that gastric juice could be collected for analysis of total acidity, free acidity, volume, and pH prior to biopsy of the gastric mucosa. The specimens of mucosa were fixed in buffered OsO(4) and embedded in n-butyl methacrylate and the thin sections were stained with lead hydroxide before examination in the electron microscope. A majority of parietal cells showed an alteration of fine structure during stimulation of gastric acid secretion by a number of different techniques (electrical vagal stimulation, histamine administration, or insulin injection). The changes in fine structure affected mainly the smooth surfaced vesicular elements and the intracellular canaliculi in the cytoplasm of the cell. The mitochondria also appeared to be involved to some extent. During acid secretion a greater concentration of smooth surface profiles is found adjacent to the walls of the intracellular canaliculi; other parietal cells exhibited a marked decrease in number of smooth surfaced elements. Intracellular canaliculi, always present in non-acid-secreting oxyntic cells, develop more extensively in cells of acid-secreting gastric glands. The surface area of these canaliculi is greatly increased by the elaboration of a large number of closely approximated and elongated microvilli. Still other parietal cells apparently in a different stage of the secretory cycle exhibit non-patent canaliculi lacking prominence; such cells have very few smooth surfaced vesicular elements. These morphological findings correlated with the acid-secretory state of the stomach provide evidence that the parietal cell participates in the process of acid secretion. |
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Authors:
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A W Sedar; M H Friedman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of biophysical and biochemical cytology Volume: 11 ISSN: 0095-9901 ISO Abbreviation: J Biophys Biochem Cytol Publication Date: 1961 Nov |
Date Detail:
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Created Date: 2010-06-22 Completed Date: 2010-06-22 Revised Date: 2010-09-28 |
Medline Journal Info:
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Nlm Unique ID: 17840020R Medline TA: J Biophys Biochem Cytol Country: United States |
Other Details:
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Languages: eng Pagination: 349-63 Citation Subset: - |
Affiliation:
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Daniel Baugh Institute of Anatomy and the Department of Physiology, Jefferson Medical College of Philadelphia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): J Biophys Biochem Cytol ISSN: 0095-9901 Publisher: The Rockefeller University Press |
Article Information Download PDF  Copyright © Copyright, 1961, by The Rockefeller Institute Press Received Day: 14 Month: 3 Year: 1961 Print publication date: Day: 1 Month: 11 Year: 1961 Volume: 11 Issue: 2 First Page: 349 Last Page: 363 ID: 2225153 PubMed Id: 19866597 |
| CORRELATION OF THE FINE STRUCTURE OF THE GASTRIC PARIETAL CELL (DOG) WITH FUNCTIONAL ACTIVITY OF THE STOMACH | |
| A. W. Sedar | |
| M. H. F. Friedman | |
| From the Daniel Baugh Institute of Anatomy and the Department of Physiology, Jefferson Medical College of Philadelphia |
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