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Correlation of fasting serum apolipoprotein B-48 with coronary artery disease prevalence.
MedLine Citation:
PMID:  22587365     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Eur J Clin Invest 2012 ABSTRACT: Background  Postprandial hyperlipidemia partially refers to the postprandial accumulation of chylomicrons and chylomicron remnants (CM-R). Many in vitro studies have shown that CM-R has highly atherogenic properties, but consensus is lacking on whether CM-R accumulation correlates with the development of atherosclerotic cardiovascular diseases. We investigated the correlation between CM-R accumulation and the prevalence of coronary artery disease (CAD). Design  Subjects who received a coronary angiography and did not take any lipid-lowering drugs (n = 189) were enrolled. Subjects with coronary artery stenosis (≥ 75%) were diagnosed as CAD. Biochemical markers for glucose and lipid metabolism including fasting apolipoprotein (apo) B-48 concentration were compared between CAD patients (n = 96) and age-, sex-, and body mass index (BMI)-matched non-CAD subjects without overt coronary stenosis (< 75%) (n = 67). We tried to determine which metabolic parameters were correlated with the prevalence of CAD by multiple logistic regression analysis, and whether or not the combination of high apo B-48 and other coronary risk factors (high triglyceride, low HDL-C, high HbA1c or low adiponectin levels) increased the prevalence of CAD. Results  Fasting serum apo B-48 levels were significantly higher in CAD patients than in non-CAD subjects (3·9 ± 2·4 vs. 6·9 ± 2·6 μg/mL, P < 0·0001) and had the most significant correlation with the existence of CAD. The clustering of high fasting apo B-48 levels (> 4·34 μg/mL, the cut-off value) and other coronary risk factors were found to be associated with a stronger risk of CAD compared with single high fasting apo B-48 levels. Conclusion  Fasting serum apo B-48 levels significantly correlated with the prevalence of CAD.
Authors:
Daisaku Masuda; Taizo Sugimoto; Ken-Ichi Tsujii; Miwako Inagaki; Kazuhiro Nakatani; Miyako Yuasa-Kawase; Kazumi Tsubakio-Yamamoto; Tohru Ohama; Makoto Nishida; Masato Ishigami; Toshiharu Kawamoto; Akifumi Matsuyama; Naohiko Sakai; Issei Komuro; Shizuya Yamashita
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-18
Journal Detail:
Title:  European journal of clinical investigation     Volume:  -     ISSN:  1365-2362     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.
Affiliation:
Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan Sugimoto Clinic, Osaka, Osaka, Japan Tsujii Clinic, Suita, Osaka, Japan Health Care Center, Osaka University, Toyanaka, Osaka, Japan Department of Biomedical Informatics, Division of Health Sciences, Osaka University Graduate School of Medicine, Suita, Osaka, Japan Kure Heart Center, National Hospital Organization Kure Medical Center, Kure, Hiroshima, Japan Department of Somatic Stem Cell Therapy, Institute of Biomedical Research and Innovation, Foundation for Biomedical Research and Innovation, Kobe, Hyogo, Japan Sakai Clinic, Moriguchi, Osaka, Japan.
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