| Correlation of fasting serum C-peptide and insulin with markers of metabolic syndrome-X in a homogenous Chinese population with normal glucose tolerance. | |
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MedLine Citation:
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PMID: 10189006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We surveyed 1447 men and 1800 women aged 30 years (mean 46.7 years) with normal glucose tolerance in Kin-Chen, Kinmen. Correlations of fasting serum insulin and C-peptide with various clinical and biochemical parameters were analyzed by multiple linear regression analysis. Women had significantly higher levels of insulin than men (98+/-43 vs. 91+/-43 pM, p<0.0001), yet they also had a more favorable cardiovascular risk profile. Insulin was positively associated with the female sex, height, body mass index, waist-to-hip ratio, serum triglyceride, total cholesterol, uric acid, and fasting plasma glucose, and was negatively associated with age, smoking, and high-density lipoprotein cholesterol. Independent correlates for C-peptide were similar to those of insulin, except for the addition of mean blood pressure and the exclusion of age and total cholesterol. Significant interaction of sex-body mass index (coefficient = -0.0051, p = 0.0232) was detected for C-peptide only. In conclusion, both fasting serum insulin and C-peptide are quantitatively associated with cardiovascular risk factors in this homogeneous Chinese population with normal glucose tolerance. The female sex is independently associated with higher insulin and C-peptide levels, and the strength of the positive association between the female sex and C-peptide reduces when the body mass index increases. |
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Authors:
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C H Chen; S T Tsai; P Chou |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of cardiology Volume: 68 ISSN: 0167-5273 ISO Abbreviation: Int. J. Cardiol. Publication Date: 1999 Feb |
Date Detail:
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Created Date: 1999-05-21 Completed Date: 1999-05-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: IRELAND |
Other Details:
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Languages: eng Pagination: 179-86 Citation Subset: IM |
Affiliation:
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Department of Social Medicine, National Yang-Ming University, Veterans General Hospital-Taipei, Taipei, Taiwan. chench@vghtpe.gov.tw |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Asian Continental Ancestry Group* Biological Markers / blood Blood Glucose / metabolism* Body Mass Index C-Peptide / blood* China / ethnology Fasting / blood* Female Glucose Tolerance Test Humans Insulin / blood* Insulin Resistance Male Microvascular Angina / blood*, ethnology Middle Aged Questionnaires Retrospective Studies Sex Characteristics |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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