Document Detail


Correlation of disease spectrum among four Dengue serotypes: a five years hospital based study from India.
MedLine Citation:
PMID:  20563439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The recognition of DF (DHF Dengue Hemorrhagic Fever) is very complicated due to occurrence of a wide spectrum of clinical signs and symptoms during acute phase of illness. Moreover, presence of four serotypes further complicates the prognosis. To investigate the predictors of disease severity and elucidate the prognostic markers among four dengue serotypes, this study was conducted on 320 inpatients having acute febrile illness clinically suspected as DI, over a period of five years. Dengue serotypes were confirmed by multiplex reverse transcriptase (RT)-PCR. Eighty patients were positive for DI with presence of Den-1, Den-2, Den-3, and Den-4 in 8, 35, 27 and 10 patients, respectively. The severe clinical manifestations, abdominal pain and hepatomegaly, were comparatively higher in Den-2 patients. Liver aminotransferases levels were also higher in Den-2 patients (app. 5 fold). This study clearly indicates the hyperendemicity of all dengue serotypes. Nucleotide sequencing of Envelope region revealed that the presently emerged Den-3 belongs to type III, having high homology with genotype responsible for number of outbreaks in 1980s. The re-emergence of this deadly type can be suspected to cause more outbreaks in future and is a matter of great concern.
Authors:
Rajni Kumaria
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases     Volume:  14     ISSN:  1678-4391     ISO Abbreviation:  Braz J Infect Dis     Publication Date:    2010 Mar-Apr
Date Detail:
Created Date:  2010-06-21     Completed Date:  2010-09-20     Revised Date:  2011-10-03    
Medline Journal Info:
Nlm Unique ID:  9812937     Medline TA:  Braz J Infect Dis     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  141-6     Citation Subset:  IM    
Affiliation:
Singapore-MIT Alliance for Research and Technology, National University of Singapore, Singapore. rankumaria@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Dengue / diagnosis,  epidemiology,  virology*
Dengue Hemorrhagic Fever / diagnosis,  epidemiology,  virology
Dengue Virus / classification,  genetics*,  isolation & purification
Genotype
Humans
India / epidemiology
Phylogeny
RNA, Viral / analysis
Reverse Transcriptase Polymerase Chain Reaction
Serotyping
Chemical
Reg. No./Substance:
0/RNA, Viral
Comments/Corrections
Comment In:
Braz J Infect Dis. 2011 Mar-Apr;15(2):184-5   [PMID:  21503411 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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