Document Detail


Correlation of connexin43 expression and late ventricular potentials in nonischemic dilated cardiomyopathy.
MedLine Citation:
PMID:  14639017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nonischemic dilated cardiomyopathy (DCM) is associated with a high risk of sudden cardiac death. Signal-averaged electrocardiography (SAECG) is a useful clinical tool for detecting late ventricular potentials (LP). Gap junction alterations have recently been shown to be involved in the pathogenesis of ventricular arrhythmias in DCM; however, the possible relationship between gap junctional connexin43 (C x 43) expression and SAECG has not yet been evaluated. In the present study 16 patients (47+/-13 years) with DCM who had undergone SAECG testing were evaluated. In each patient, the expression of C x 43 proteins was qualitatively and quantitatively determined using immunoconfocal microscopy and right ventricular biopsy specimens. The level of expression of C x 43 protein was defined as the proportion of tissue area occupied by C x 43 (percent tissue area) in each test area. The abundance and distribution of the C x 43 signal was assessed in relation to LP. Late ventricular potentials were positive in 5 patients (LP (+) group) and negative in 11 patients (LP (-) group). The incidence of sustained ventricular tachycardia in the LP (+) group was higher than that in the LP (-) group (80% vs 18%, p=0.04). The percent tissue area of C x 43 in the LP (+) group was significantly lower than that in the LP (-) group (p=0.02). Furthermore, C x 43 protein in the LP (+) group was distributed more heterogeneously than that in the LP (-) group (p=0.001). The heterogeneous expression of C x 43 protein may contribute to impaired ventricular conduction, which may be related to the LP detected on SAECG.
Authors:
Hidetsuna Kitamura; Akihiro Yoshida; Yoshio Ohnishi; Katsunori Okajima; Akihiko Ishida; Erdulfo J Galeano; Shinya Kubo; Kouji Fukuzawa; Takatsugu Takano; Mitsuhiro Yokoyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  67     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-25     Completed Date:  2004-07-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1017-21     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cardiomyopathy, Dilated / genetics*
Connexin 43 / genetics*
Electrocardiography
Female
Gene Expression Regulation / genetics*
Humans
Immunohistochemistry
Male
Middle Aged
Ventricular Dysfunction / genetics,  pathology,  physiopathology*
Ventricular Function, Left / physiology*
Chemical
Reg. No./Substance:
0/Connexin 43

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