Document Detail

Correlation of catecholamine levels in the bed nucleus of the stria terminalis and reduced sexual behavior in middle-aged male rats.
MedLine Citation:
PMID:  18693221     Owner:  NLM     Status:  MEDLINE    
The correlation between dopamine (DA) and norepinephrine (NE) levels in the bed nucleus of the stria terminalis (BNST) and male sexual behavior was examined in middle-aged rats. Male rats (18-19 months) were divided into: (a) Group MIE, consisting of rats showing mounts, intromissions, and ejaculations; (b) Group MI, composed of rats showing mounts and intromissions, but no ejaculation; and (c) Group NC, consisting of noncopulators. Young adult rats (4-5 months) displaying complete copulatory behavior were used as the control. Tissue levels of DA, NE, and DA metabolites in the BNST were measured by high-pressure liquid chromatography. DA, but not NE, levels in MIE rats were significantly lower than those in young controls. DA and NE levels in MIE rats were significantly higher than those in NC rats. These results suggest that DA and NE in the BNST might play an important role in the control of male sexual behavior in middle-aged rats.
Joyce C Chen; Houng-Wei Tsai; Kuei-Ying Yeh; Mei-Yun Tai; Yuan-Feen Tsai
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  63     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-09-12     Revised Date:  2008-10-15    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  678-82     Citation Subset:  AIM; IM    
Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Age Factors
Chromatography, High Pressure Liquid
Dopamine / metabolism*
Homovanillic Acid / metabolism
Norepinephrine / metabolism*
Rats, Long-Evans
Septal Nuclei / metabolism*
Sexual Behavior, Animal / physiology*
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 51-41-2/Norepinephrine

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