Document Detail

Correlation beween AAI-index and the BIS-index during propofol hypnosis: a clinical study.
MedLine Citation:
PMID:  12885175     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the degree of linearity and correlation between the anaesthetic depth indices BIS and AAI over a wide range of hypnotic depth using propofol. METHODS: 20 ASA I patients were studied during propofol induction. Co-induction with 0.05 mg fentanyl and 30 mg propofol iv before initiation of the study. Thereafter repeated doses of propofol 0.5 mg/kg iv. every minute until BIS < 30. Loss of responsiveness to verbal command was determined by repeated loud commands to the patient. BIS (Aspect 2000 XP, BIS algorithm 4.0, system rev. 3.12, Aspect Medical Systems; Natick, MA, U.S.A.) and AAI-index (A-Line Auditory Evoked Potential Monitor, version 1.4, Danmeter A/S; Odense, Denmark) were determined simultaneously (n = 15). BIS alone without acoustical stimulation was studied in a control group (n = 5). MAIN RESULTS: Both indices decreased with increasing dose, and there was a high correlation between the two (r2 = 0.82). The indices showed however different values and while BIS were quite linear, the AAI-index had a more on-offb ehaviour. CONCLUSION: The AAI-index correlates with the BIS-index during propofol hypnosis in the absence of surgical stimulation. Neither the BIS-index, heart rate, nor systemic blood pressure were influenced by the acoustical stimulation from the A-line monitor. Both indices decreased in relation to increasing doses of propofol, but the AAI-index was lower both before becoming unconscious, during transition to unconsciousness, and during the deeper levels of sedation. The AAI-index lacks linearity at both very low and higher levels of propofol sedation with a nearly on-off behaviour for wakefulness vs hypnosis.
Russell E Anderson; Gunilla Barr; Jan G Jakobsson
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of clinical monitoring and computing     Volume:  17     ISSN:  1387-1307     ISO Abbreviation:  J Clin Monit Comput     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2003-07-29     Completed Date:  2003-10-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9806357     Medline TA:  J Clin Monit Comput     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  325-9     Citation Subset:  IM    
Department of Cardiothoracic Anaesthetics and Intensive Care, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Anesthesia, General*
Anesthetics, Intravenous / pharmacology*
Evoked Potentials, Auditory*
Hypnosis, Anesthetic / classification*
Middle Aged
Monitoring, Physiologic
Propofol / pharmacology*
Regression Analysis
Sensitivity and Specificity
Reg. No./Substance:
0/Anesthetics, Intravenous; 2078-54-8/Propofol

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