| Correlation between visual function and photoreceptor inner/outer segment junction in patients with retinitis pigmentosa. | |
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MedLine Citation:
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PMID: 18188175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To determine whether a significant correlation exists between the visual acuity or foveal thickness and the status of the inner and outer segment junction (IS/OS) of the photoreceptor in patients with retinitis pigmentosa (RP). METHODS: Three hundred eyes of 163 patients with RP were examined with the optical coherence tomography (OCT). The IS/OS appeared as a distinct, highly reflective line just vitread of the retinal pigment epithelium in the OCT3 images. The IS/OS line was graded into three groups. The correlations between the grade of the IS/OS and age, best-corrected visual acuity (BCVA), and central foveal thickness (CFT) were determined. RESULTS: Grade 1 included 93 eyes (31.0%) in which an IS/OS line was not seen, Grade 2 included 67 eyes (22.3%) with an abnormal IS/OS, and Grade 3 included 140 eyes (46.7%) with a normal IS/OS. The correlation between the IS/OS grade and age was not significant (P=0.5536). The IS/OS grade was significantly correlated with BCVA and CFT (both P<0.0001). The BCVA was significantly better in Grade 3 eyes than Grades 1 and 2 (both P<0.0001). The CFT was significantly thinner in Grade 1 eyes than in Grades 2 and 3 (both P<0.0001). In Grade 3, the mean length of the IS/OS was 2.51+/-1.42 mm (+/-SD). The length of the IS/OS was significantly correlated with the BCVA (P<0.0001, r=-0.375). CONCLUSIONS: The presence of the IS/OS was associated with better visual acuity and thicker fovea in RP patients. The absence of an IS/OS may reflect a foveal dysfunction in RP patients. |
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Authors:
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S Aizawa; Y Mitamura; T Baba; A Hagiwara; K Ogata; S Yamamoto |
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Publication Detail:
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Type: Journal Article Date: 2008-01-11 |
Journal Detail:
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Title: Eye (London, England) Volume: 23 ISSN: 1476-5454 ISO Abbreviation: Eye (Lond) Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-13 Completed Date: 2010-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703986 Medline TA: Eye (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 304-8 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Japan. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Child Cross-Sectional Studies Female Fovea Centralis / pathology Humans Male Middle Aged Retinal Photoreceptor Cell Inner Segment / pathology* Retinal Photoreceptor Cell Outer Segment / pathology* Retinitis Pigmentosa / pathology*, physiopathology Severity of Illness Index Tomography, Optical Coherence Visual Acuity / physiology* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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