Document Detail

Correlation between ventricular enlargement and white matter changes.
MedLine Citation:
PMID:  18191949     Owner:  NLM     Status:  MEDLINE    
The clinical significance of white matter changes including periventricular hyperintensity (PVH) and deep white matter hyperintensity (DWMH) on MRI in patients with normal pressure hydrocephalus is unclear. We investigated the correlation between ventricular size and white matter changes in healthy individuals. We performed MRI in 683 (mean age 59; 55% men) neurologically normal adults without a history or radiological findings of brain disease or trauma, who were undergoing brain health screening. The correlation between Evans' index and severity of white matter changes was analyzed. Multiple linear regression analysis was used to identify the main clinical factors influencing ventricular enlargement and white matter changes. Evans' index was 0.248+/-0.026 (mean+/-SD). Incidence of PVH was 40% and DWMH was 29%. Evans' index was weakly correlated with PVH grading (rho=0.24; P<.01) and DWMH grading (rho=0.24; P<.01). Multiple linear regression analysis showed that age (beta=0.034; SE=0.003) diastolic blood pressure (0.004; 0.002), Evans' index (0.019; 0.009), and a history of hypertension (0.173; 0.053) had a significant impact on PVH grade, whereas age (0.030; 0.003) and history of hypertension (0.224; 0.049) were related to DWMH grade. It was suggested that there is an independent correlation between ventricular enlargement and PVH in normal adults. This finding in a normal population could be due to the presence of preclinical disease, but its bearing on the changes that occur in normal pressure hydrocephalus remain uncertain at the present time.
Yuichiro Inatomi; Toshiro Yonehara; Yoichiro Hashimoto; Teruyuki Hirano; Makoto Uchino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-14
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  269     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Department of Neurology, Stroke Center, Saiseikai Kumamoto Hospital, Chikami 5-3-1, Kumamoto 861-4193, Japan.
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MeSH Terms
Cerebral Ventricles / pathology
Demyelinating Diseases / complications*,  pathology*
Hydrocephalus, Normal Pressure / complications*,  pathology*
Linear Models
Magnetic Resonance Imaging
Middle Aged
Retrospective Studies
Severity of Illness Index

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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