Document Detail


Correlation between venous stump pressure and brain damage after cortical vein occlusion: an experimental study.
MedLine Citation:
PMID:  9120634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A canine model of cortical vein occlusion was used to evaluate whether data obtained from monitoring venous stump pressure could help predict cerebral infarction after venous obstruction. Following bilateral parasagittal craniotomy, the cortical vein in each hemisphere was temporarily occluded and the increase in pressure was directly measured. Permanent venous obstruction was subsequently produced, and parenchymal brain damage 24 hours later was classified as: Stage 0, no parenchymal damage; Stage I, mild edema; Stage II, moderate parenchymal edema and/or ischemic changes in neurons; and Stage III, moderate-to-severe hemorrhage. The histological stages correlated closely with the rise in venous pressure: mean pressure increases (+/- standard deviation) were 5.5 +/- 2.9 mm Hg in hemispheres graded as Stage 0 (12 hemispheres), 7.7 +/- 3.2 mm Hg in those graded as Stage I (five), 11.2 +/- 4.1 mm Hg in those classed as Stage II (five), and 16.4 +/- 5 in those categorized as Stage III (seven). There were significant differences between Stages 0 and II (p < 0.01) and between Stages 0 and III (p < 0.001). Disruption of the blood-brain barrier as indicated by extravasation of Evans blue dye correlated well with the pressure increment. These results may indicate the threshold for injury after cortical venous occlusion. Venous stump pressure measurements obtained during a test occlusion may be a useful adjunct in predicting brain damage and may be helpful for intraoperative vessel selection for venous resection.
Authors:
Y Yoshimoto; M Endo; T Mori; S Wakai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  86     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-04-23     Completed Date:  1997-04-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  694-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Neurosurgery, Dokkyo University School of Medicine, Tochigi, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / pathology
Brain Damage, Chronic / etiology*
Cerebral Veins / physiopathology*
Constriction, Pathologic
Dogs
Female
Male
Vascular Diseases / complications*,  pathology,  physiopathology*
Venous Pressure*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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