| Correlation between uteroplacental three-dimensional power Doppler indices and true uterine blood flow: evaluation in a pregnant sheep model. | |
| | |
MedLine Citation:
|
PMID: 20617508 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
OBJECTIVES: Three-dimensional (3D) Doppler quantification within the uteroplacental unit could be of great help in understanding and screening for pre-eclampsia and intrauterine growth restriction. Yet the correlation between 3D Doppler indices and true blood flow has not been confirmed in vivo. The aim of this study was to evaluate this correlation in a pregnant sheep model. METHODS: A blood flow quantitative sensor and a controllable vascular occlusion system were placed around the common uterine artery in seven sheep in late pregnancy, while all the other arterial supplies were ligated. Several occlusion levels were applied, from 0 to 100%, simultaneously with 3D Doppler acquisitions of several placentomes, using standardized settings. Each placentome was analyzed using VOCAL™ (Virtual Organ Computer-aided AnaLysis) software. The correlation between true blood flow and Doppler indices (vascularization index (VI), flow index (FI) and vascularization flow index (VFI)) was evaluated, together with measurement reproducibility. RESULTS: Forty-eight acquisitions were analyzed. All 3D Doppler indices were significantly correlated with true blood flow. Higher correlations were observed for VI and VFI (r = 0.81 (0.74-0.87), P < 0.0001 and r = 0.75 (0.67-0.82), P < 0.0001) compared with FI (r = 0.53 (0.38-0.64) P < 0.0001). Both intra- and interobserver reproducibility were high, with intraclass correlation coefficients of at least 0.799. CONCLUSION: This is the first in-vivo experimental study confirming a significant correlation between true blood perfusion and quantitative 3D Doppler indices measured within the uteroplacental unit. These results confirm the potential usefulness of 3D Doppler ultrasound for the assessment of placental vascular insufficiency both in clinical cases and in a research setting. |
| | |
Authors:
|
O Morel; F Pachy; P Chavatte-Palmer; M Bonneau; E Gayat; P Laigre; D Evain-Brion; V Tsatsaris |
Related Documents
:
|
16134808 - Blood flow measurements in studies of macro- and microcirculation. 12604118 - Mp3 compression of doppler ultrasound signals. 2943068 - Comparison of cw doppler ultrasound spectra with the spectra derived from a flow visual... 1721078 - Development of collateral circulation in a replanted rat hindlimb model. 10845818 - Spurious metabolic acidosis in hemodialysis patients. 2987418 - Blood flow and oxygen utilisation in the contralateral cerebral cortex of patients with... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology Volume: 36 ISSN: 1469-0705 ISO Abbreviation: Ultrasound Obstet Gynecol Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9108340 Medline TA: Ultrasound Obstet Gynecol Country: England |
Other Details:
|
Languages: eng Pagination: 635-40 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 ISUOG. Published by John Wiley & Sons, Ltd. |
Affiliation:
|
INRA, UMR 1198 Developmental Biology and Reproduction, Jouy-en-Josas, France. olivier.morel17@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Second-trimester assessment of gestational age in twins: validation of singleton biometry charts.
Next Document: Longitudinal changes in uterine, umbilical and fetal cerebral Doppler indices in late-onset small-fo...