Document Detail

Correlation between urine and blood concentrations, and dietary intake of cadmium and lead among women in the general population of Japan.
MedLine Citation:
PMID:  10787131     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine whether lead (Pb) in urine and cadmium (Cd) in blood, especially the former, can be used as markers of environmental exposure of general populations to these metals. METHODS: Between 1991 and 1998, spot urine and peripheral blood samples, together with 24 h duplicates of food intake were collected from 607 non-smoking adult women in 30 survey sites (SS) in seven administrative regions all over Japan. Urine, blood and food duplicate samples were analyzed by inductively-coupled plasma spectrometry, for Cd and Pb in urine (Cd-U and Pb-U), in blood (Cd-B and Pb-B) and in food duplicates (Cd-F and Pb-F). Correlation between the measurements was examined by regression analysis. RESULTS: The Cd-B correlated closely with Cd-U, and both Cd-B and Cd-U with Cd-F, on an individual basis (n = 607), on an SS basis (n = 30) and on a regional basis (n = 7). The Pb-U however did not correlate with Pb-B on a regional basis although they correlated with each other when analyzed on an individual as well as SS basis. Moreover, the correlation coefficients between Pb-U and Pb-B were much smaller than those between Cd-U and Cd-B. Neither Pb-U nor Pb-B showed significant correlation with Pb-F on any levels of statistical analysis. CONCLUSIONS: Both Cd-B and Cd-U can be employed as biomarkers of environmental Cd exposure. The reliability of Pb-U for use in place of Pb-B appeared to be small.
S Shimbo; Z W Zhang; C S Moon; T Watanabe; H Nakatsuka; N Matsuda-Inoguchi; K Higashikawa; M Ikeda
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International archives of occupational and environmental health     Volume:  73     ISSN:  0340-0131     ISO Abbreviation:  Int Arch Occup Environ Health     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-19     Completed Date:  2000-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7512134     Medline TA:  Int Arch Occup Environ Health     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  163-70     Citation Subset:  IM    
Department of Food and Nutrition, Kyoto Women's University, Japan.
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MeSH Terms
Cadmium / administration & dosage,  blood*,  urine*
Food Analysis
Lead / administration & dosage,  blood*,  urine*
Mass Spectrometry / methods
Middle Aged
Population Surveillance
Regression Analysis
Reg. No./Substance:
7439-92-1/Lead; 7440-43-9/Cadmium

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