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Correlation between ultrasound diagnosis and autopsy findings of fetal malformations.
MedLine Citation:
PMID:  22905306     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: to compare ultrasound (US) and autopsy findings of fetal malformations in second trimester terminations of pregnancy to evaluate the degree of agreement between US and fetal autopsy.
METHODS: in this study, all second trimester termination of pregnancy between 2003-2010 were considered. US and autopsy findings were compared and all cases were classified into five categories according to the degree of agreement between US and pathology (A1: full agreement between US and autopsy; A2: autopsy confirmed all US findings but revealed additional anomalies 'rarely detectable' prenatally; B: autopsy demonstrated all US findings but revealed additional anomalies 'detectable' prenatally; C: US findings were only partially demonstrated at fetal autopsy; D: total disagreement between US and autopsy).
RESULTS: 144 cases were selected. In 49% of cases there was total agreement between US and autopsy diagnosis (A1). In 22% of cases additional information were about anomalies 'not detectable' by US (A2). In 12% of cases autopsy provided additional information about anomalies not observed but 'detectable' by US (B). In 13% of cases some anomalies revealed at US, such as valve insufficiencies, pericardial and pleural effusions, were not verified at autopsy (C). Total lack of agreement was noted only in 4% of cases (D). Main areas of disagreement concerned cardiovascular, CNS and complex malformations. The degree of agreement was higher if malformations were diagnosed in a tertiary center.
CONCLUSIONS: this study shows an overall high degree of agreement between definitive US and autopsy findings in second trimester termination of pregnancy for fetal malformations. Autopsy reveals to be the best tool to diagnose malformations and often showed other abnormalities of clinical importance not detected by US, but sometimes also US could provide additional information about functional anomalies because US is a dynamic examination.
Authors:
Antonella Vimercati; Silvana Grasso; Marinella Abruzzese; Annarosa Chincoli; Alessandra de Gennaro; Angela Miccolis; Gabriella Serio; Luigi Selvaggi; Fabiana Divina Fascilla
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of prenatal medicine     Volume:  6     ISSN:  1971-3290     ISO Abbreviation:  J Prenat Med     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-08-20     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101522906     Medline TA:  J Prenat Med     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  13-7     Citation Subset:  -    
Affiliation:
Department of Obstetric and Gynecology, University of Bari, Italy.
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