Document Detail


Correlation between tumor induction and the large external transformation sensitive protein on the cell surface.
MedLine Citation:
PMID:  1068469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The distribution on the cell surface of the large external LETS protein that is transformation sensitive of normal, transformed and tumorigenic cells was examined by immunofluorescent staining. A correlation was established between the expression of fibril-like LETS protein and the oncogenic capabilities of a series of adenovirus-transformed cell lines. In cells expressing a transformed phenotype in vitro, LETS protein is only detected in cell-cell contact areas, wheras in "untransformed" cells LETS protein is distributed over the cell surface. Transformed cells capable of inducing invasive tumors, and the cells of established tumor lines, have low or undetectable levels of LETS protein, as measured by this method. The results indicate that LETS protein has a role in cell-cell adhesion and that reduced expression of this protein at the cell surface is related to the oncogenic phenotype. This relationship has been established for experimentally induced and spontaneous tumors.
Authors:
L B Chen; P H Gallimore; J K McDougall
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  73     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3570-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenoviridae
Cell Line
Cell Transformation, Neoplastic* / pathology
Cryoglobulins* / analysis,  immunology
Membrane Proteins* / analysis,  immunology
Neoplasm Proteins* / analysis,  immunology
Neoplasms, Experimental / etiology*,  immunology
Chemical
Reg. No./Substance:
0/Cryoglobulins; 0/Membrane Proteins; 0/Neoplasm Proteins
Comments/Corrections

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