Document Detail


Correlation between transcranial Doppler ultrasonography and regional cerebral blood flow in experimental intracranial hypertension.
MedLine Citation:
PMID:  9056619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Transcranial Doppler ultrasonography (TCD) provides useful information on cerebral circulation even under raised intracranial pressure. This study was designed to evaluate the correlation between cerebral blood flow (CBF) and TCD parameters under conditions of boundary intracranial hypertension that can cause brain death. METHODS: Intracranial pressure was raised by inflation of a supratentorial epidural balloon in cats. Blood flow velocity of the middle cerebral artery was measured transorbitally with microvascular Doppler sonography, and intracranial pressure and CBF were evaluated. RESULTS: In this study, four characteristic flow patterns were observed, appearing in the following order with progressive increases in intracranial pressure: sharp wave, systolic flow, systolic spike, and no flow. These flow patterns showed a significant correlation with flow velocity, CBF, the pulsatility index, and cerebral perfusion pressure. The systolic-spike and no-flow patterns and pulsatility index over 4.0 indicated decreased CBF, under 10% of control values. CONCLUSIONS: The critical level of brain circulation can be detected by Doppler sonography, indicating that TCD is available as a tool for the assessment of cerebral circulatory arrest in brain death.
Authors:
H Nagai; K Moritake; M Takaya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  28     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-04-04     Completed Date:  1997-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  603-7; discussion 608     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Shimane Medical University, Japan. nogeka@shimane-med.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity
Brain Death / physiopathology,  ultrasonography
Cats
Cerebrovascular Circulation / physiology*
Electroencephalography
Female
Intracranial Pressure
Male
Microcirculation / physiology
Periodicity
Pseudotumor Cerebri / physiopathology*,  ultrasonography*
Ultrasonography, Doppler, Transcranial*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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