Document Detail

Correlation between single nephron glomerular filtration rate and filtration area in superficial glomeruli of developing rats.
MedLine Citation:
PMID:  3227883     Owner:  NLM     Status:  MEDLINE    
Single nephron glomerular filtration rate (SNGFR) was correlated to the area of the glomerular basement membrane (GBM) determined by stereological techniques in rats between 20 and 40 days of age. Single nephron glomerular filtration rate increased 8.4 times in parallel with a twofold increase in GBM area. The much greater postnatal increase in SNGFR than in GBM area demonstrates that the increase in GBM area cannot account for the entire increase in SNGFR. Instead a combination of other factors influencing SNGFR most likely determines the largest part of the increase in SNGFR during this period. Thus, the drop in vascular resistance known to occur during maturation will increase the renal blood flow and may cause the filtration process to turn from a state of filtration equilibrium to or close to disequilibrium, thereby increasing GFR. Additional increase in GFR may be due to an increased net driving force for filtration and/or changed hydraulic permeability.
L Larsson; G Celsi; A B Maunsbach
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  132     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1989-03-27     Completed Date:  1989-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  413-7     Citation Subset:  IM    
Department of Paediatrics, Karolinska Institute, St Göran's Children's Hospital, Stockholm, Sweden.
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MeSH Terms
Age Factors
Basement Membrane / physiology,  ultrastructure
Glomerular Filtration Rate*
Kidney Glomerulus / growth & development,  physiology*,  ultrastructure
Nephrons / physiology*
Rats, Inbred Strains
Renal Circulation
Vascular Resistance

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