| Correlation between serum prostate-specific antigen and alpha-1-antitrypsin in men without and with prostate cancer. | |
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MedLine Citation:
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PMID: 16581345 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prostate specific antigen (PSA) is frequently used for prostate cancer (PCa) screening, but serum levels are also increased by prostate inflammation. Elevations in serum levels of alpha1-antitrypsin (ATT), a marker of inflammation, in cancer patients are well documented. However, an association between PSA and ATT has never been investigated. The authors, therefore, measured serum acute phase proteins (APPs) ATT, alpha1-acid glycoprotein, C-reactive protein, and alpha1-antichymotrypsin in 174 men without and 34 with newly diagnosed untreated PCa (38-80 years old). As expected, men with PCa had higher mean PSA levels than those without PCa (P < 0.00001). Men with PCa and those without PCa but with PSA >2 ng/mL (n = 68) had significantly higher ATT concentrations than those without these conditions (n = 106) (mean +/- SEM g/L): 1.94+/-0.083, 1.92+/-0.066, 1.25+/-0.043, respectively; p <0.005). Interestingly, African-American men without PCa (n=111) had higher ATT levels than Caucasian men (n=63) (1.565+/-0.045 g/l versus 1.395+/-0.056 g/l; p <0.005); and differences persisted in men with PSA >2 ng/ml (2.094+/-0.07 g/l versus 1.593 for all0.095 g/l; p<0.0002). There were no differences among groups in the levels of other APP. ATT showed the strongest correlation with PSA (r = 0.346 to 0.395; p <0.001) than any other APP (r < or =0.245). Our data suggest that men with PCa have higher ATT levels than those without PCa; and African-American men without PCa have higher ATT levels than Caucasian men. The possible implications of elevated ATT levels in African-American men on the risk of PCa are discussed. |
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Authors:
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Solo Kuvibidila; Walter Rayford |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of laboratory and clinical medicine Volume: 147 ISSN: 0022-2143 ISO Abbreviation: J. Lab. Clin. Med. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-03 Completed Date: 2006-05-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375375 Medline TA: J Lab Clin Med Country: United States |
Other Details:
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Languages: eng Pagination: 174-81 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics and the Department of Urology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA. skuvib@lsuhsc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute-Phase Proteins
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metabolism Adult African Americans Aged Aged, 80 and over Case-Control Studies European Continental Ancestry Group Humans Inflammation Mediators / blood Male Middle Aged Prostate-Specific Antigen / blood* Prostatic Neoplasms / blood* Risk Factors Tumor Markers, Biological / blood alpha 1-Antitrypsin / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Acute-Phase Proteins; 0/Inflammation Mediators; 0/Tumor Markers, Biological; 0/alpha 1-Antitrypsin; EC 3.4.21.77/Prostate-Specific Antigen |
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