Document Detail


Correlation between serum creatinine kinase levels and extent of muscle damage in electrical burns.
MedLine Citation:
PMID:  15475142     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between clinical course and changes of laboratory findings in patients with high-voltage electrical burns with regard to creatinine kinase activity was analyzed in order to determine the value of this prognostic parameter with regard to patients survival and risk of limb amputation. In a retrospective study 42 patients with electrical burns were reviewed. CK serum levels were determined every day during the first 10 days following submission. Analysis of data revealed a relation between strongly elevated CK levels and patients risk of limb amputation and mortality. Although further research is necessary, there is strong evidence that the amount of burned body surface area does not directly correlate with the true extent of tissue damage caused by high tension injuries. Our data suggest that the degree of muscle tissue violation corresponds with the initial excess of creatinine kinase levels in blood serum. This may be an additional factor to support the decision for early surgical decompression of electrically burned extremities and aggressive surgical management of the high-voltage burn victim. Furthermore, it may provide a prognostic parameter for the clinical outcome of these patients.
Authors:
Jürgen Kopp; Bernd Loos; Gerald Spilker; Raymund E Horch
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Burns : journal of the International Society for Burn Injuries     Volume:  30     ISSN:  0305-4179     ISO Abbreviation:  Burns     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-10-11     Completed Date:  2004-12-16     Revised Date:  2005-12-13    
Medline Journal Info:
Nlm Unique ID:  8913178     Medline TA:  Burns     Country:  England    
Other Details:
Languages:  eng     Pagination:  680-3     Citation Subset:  IM    
Affiliation:
Department of Plastic and Hand Surgery, University Medical Center, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstrasse 12, Erlangen D-91054, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Amputation
Biological Markers / blood
Burns, Electric / enzymology*,  surgery
Child
Creatine Kinase / blood*
Fascia / surgery
Female
Humans
Male
Middle Aged
Muscle, Skeletal / injuries*
Prognosis
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Biological Markers; EC 2.7.3.2/Creatine Kinase
Comments/Corrections
Comment In:
Burns. 2005 Aug;31(5):670-1   [PMID:  15993317 ]

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