| Correlation between serum biochemical markers and early amniocentesis in diagnosis of congenital fetal anomalies. | |
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MedLine Citation:
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PMID: 20192924 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A combined test performed at the 12th week of gestation enables us to classify the pregnancy as high risk (risk higher than 1:300) or low risk (risk lower than 1:300) for congenital foetal anomalies, with great accuracy of 85 - 90%. According to the available data, the frequency of false positive results is estimated at around 5%. The objective of the study was to examine possible correlation between the serum marker values and amniocentesis results in prenatal diagnostics of congenital foetal anomalies. The study included 745 pregnant women monitored by the Genetic Counselling Service of the Clinic of Gynaecology and Obstetrics of the Clinics Centre Kragujevac. The subjects were included in the study under condition that CRL (embryonic crown-rump length) was from 45 to 84 mm and that the gestational age was at 11-13+6 weeks. Free beta HCG and PAPP-A were determined from venous blood using commercial DPS-USA tests. Tests were based on the analytic principle of the immuno-chemiluminescence technique and were performed by application of the automatic Immulite 2000 analyzer by DPC-USA. The foetal nuchal translucency thickness (NT) and CRL were measured by Colour Doppler. The chromosome identification was performed after a certain number of cell divisions by stopping the cell division in metaphase of mitosis when the chromosomes were the most distinguishable. The foetal karyotype was prepared using G bands. In the total sample of pregnant women (n=745), there were six cases of pathological foetal karyotype. A statistical paradox in the frequency of congenital foetal anomalies in favour of younger population was noticed. A high coefficient of Spearman's rank correlation suggests great importance of the combined test in the detection of congenital foetal anomalies (p<0,05). A high consistency was also proved for components of biochemical screening and ultrasonographic markers. The combined test, as a method of prenatal screening in the first trimester of pregnancy, if used at 11 - 13+6 weeks' gestation and for CRL of 45-84 mm, has a great importance in the detection of congenital foetal anomalies. |
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Authors:
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Dragan Loncar; Mirjana Varjacic; Tanja Novakovic; Dragan Milovanovic; Slobodan Jankovic |
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Publication Detail:
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Type: Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Bosnian journal of basic medical sciences / Udru?enje basi?nih mediciniskih znanosti = Association of Basic Medical Sciences Volume: 10 ISSN: 1512-8601 ISO Abbreviation: Bosn J Basic Med Sci Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200947 Medline TA: Bosn J Basic Med Sci Country: Bosnia and Hercegovina |
Other Details:
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Languages: eng Pagination: 9-14 Citation Subset: IM |
Affiliation:
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Clinic of Gynaecology and Obstetrics, Clinics Centre Kragujevac, Zmaj Jovina 2, 34000 Kragujevac, Serbia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniocentesis* Biological Markers / blood* Chorionic Gonadotropin, beta Subunit, Human / blood* Congenital Abnormalities / blood, diagnosis* Crown-Rump Length Female Fetal Diseases / blood, diagnosis* Gestational Age Humans Nuchal Translucency Measurement Predictive Value of Tests Pregnancy Pregnancy-Associated Plasma Protein-A / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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