Document Detail


Correlation between serum adiponectin and risk factors in patients with coronary artery disease.
MedLine Citation:
PMID:  23505916     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: To investigate the correlation between serum adiponectin (ADP) and high sensitivity C-reactive protein (hsCRP) as well as risk factors in patients with coronary artery disease (CAD).
METHODS: 90 patients with coronary artery disease (CAD) who were subjected to coronary angiography were involved. Among the patients, 41 had acute myocardial infarction (AMI), 27 had unstable angina pectoris (UAP), and 22 had stable angina pectoris (SAP). 20 healthy people comprised the control group (NC). Serum ADP was measured using an enzyme linked immunosorbent assay (ELISA). hsCRP was measured using immunoturbidimetry. Cardiovascular risk factors were also investigated.
RESULTS: The serum ADP concentrations in the AMI group and the UAP group were significantly lower than those in the SAP group (p < 0.05) and the NC group (p < 0.01). The hsCRP concentrations in the AMI group and the UAP group were significantly higher than those in the SAP group (p < 0.05) and the NC group (p < 0.05). The ADP concentration was negatively correlated with the hsCRP concentration in the acute coronary syndrome group (r = -0.33, p < 0.05). Moreover, the more risk factors there were, the lower the serum ADP concentration in the CAD patients was.
CONCLUSIONS: Serum ADP is associated with CAD and cardiovascular risk factors. ADP has anti-inflammatory and anti-atherogenic properties, which may have a predictive value for the genesis and development of ACS.
Authors:
Suxin Luo; Han Lei; Qing Liu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical laboratory     Volume:  59     ISSN:  1433-6510     ISO Abbreviation:  Clin. Lab.     Publication Date:  2013  
Date Detail:
Created Date:  2013-03-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705611     Medline TA:  Clin Lab     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
Affiliation:
Department of Cardiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
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