Document Detail

Correlation between saliva and serum for human immunodeficiency virus 1 and 2 antibodies using a rapid test system.
MedLine Citation:
PMID:  8849184     Owner:  NLM     Status:  MEDLINE    
Currently, human immunodeficiency virus (HIV) tests are almost totally serum based. In situations where blood is difficult or inconvenient to obtain, a substitute to venepuncture offers an attractive alternative. The prototype OraScreen saliva dipsticks were tested on 278 samples comprising 100 normals, 100 samples from persons attending a sexually transmitted disease clinic and 78 samples from persons confirmed to have HIV. The specificity and the sensitivity of the diagnostic test for saliva was 99.5% and 94.7% respectively, when compared to a routine solid-phase enzyme-linked immunosorbent assay (ELISA) test on serum samples and Western blot test when indicated. The prototype OraScreen dipstick test shows potential for saliva testing in situations where it would be inconvenient to use blood. Further evaluation of saliva testing is warranted on a large sample population with a low prevalence of HIV infection.
Y H Leow; A Goh; P Y Lim; R K Chan; C L Goh; B A Kamarudin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the Academy of Medicine, Singapore     Volume:  24     ISSN:  0304-4602     ISO Abbreviation:  Ann. Acad. Med. Singap.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503289     Medline TA:  Ann Acad Med Singapore     Country:  SINGAPORE    
Other Details:
Languages:  eng     Pagination:  537-40     Citation Subset:  IM; X    
National Skin Centre, Singapore.
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MeSH Terms
Blotting, Western
Enzyme-Linked Immunosorbent Assay
HIV Antibodies / analysis*,  blood*
HIV Infections / diagnosis
HIV-1 / immunology*
HIV-2 / immunology*
Middle Aged
Saliva / immunology*
Sensitivity and Specificity
Reg. No./Substance:
0/HIV Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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