Document Detail

Correlation between rises in Chlamydia pneumoniae-specific antibodies, platelet activation and lipid peroxidation after percutaneous coronary intervention.
MedLine Citation:
PMID:  18350325     Owner:  NLM     Status:  MEDLINE    
We recently showed that Chlamydia pneumoniae activates platelets in vitro, with an associated oxidation of low-density lipoproteins. The aim of this study was to investigate whether C. pneumoniae is released during percutaneous coronary intervention (PCI) and, thereby, causes platelet activation and lipid peroxidation. Seventy-three patients undergoing coronary angiography and following PCI or coronary artery bypass graft (CABG) and 57 controls were included in the study. C. pneumoniae antibodies, serotonin and lipid peroxidation were measured before and 24 h, 1 month and 6 months after angiography. The results show that serum C. pneumoniae IgA concentrations were significantly higher in patients than in the controls. Furthermore, in 38% of the C. pneumoniae IgG positive patients, the C. pneumoniae IgG concentration increased 1 month after PCI. The levels of C. pneumoniae IgG antibodies 1 month after PCI correlated with plasma-lipid peroxidation (r = 0.91, P < 0.0001) and platelet-derived serotonin (r = 0.62, P = 0.02). There was no elevation in the total serum IgG 1 month after PCI. In conclusion, the present results suggest that PCI treatment of coronary stenosis releases C. pneumoniae from the atherosclerotic lesions, which leads to platelet activation and lipid peroxidation.
H Kälvegren; J Fridfeldt; P Garvin; L Wind; P Leanderson; M Kristenson; E Kihlström; T Bengtsson; A Richter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-19
Journal Detail:
Title:  European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology     Volume:  27     ISSN:  0934-9723     ISO Abbreviation:  Eur. J. Clin. Microbiol. Infect. Dis.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-10-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804297     Medline TA:  Eur J Clin Microbiol Infect Dis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  503-11     Citation Subset:  IM    
Department of Medicine and Health, Faculty of Health Sciences, Linköping University, 581 85, Linköping, Sweden.
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MeSH Terms
Antibodies, Bacterial / blood*
Atherectomy / adverse effects*
Chlamydophila pneumoniae / immunology*
Coronary Artery Bypass / adverse effects
Coronary Stenosis / surgery*
Immunoglobulin A / blood
Immunoglobulin G / blood
Lipid Peroxidation*
Longitudinal Studies
Middle Aged
Platelet Activation*
Serotonin / metabolism
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Immunoglobulin A; 0/Immunoglobulin G; 50-67-9/Serotonin

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