| Correlation between prenatal ultrasound and fetal autopsy findings in fetal anomalies terminated in the second trimester. | |
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MedLine Citation:
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PMID: 17335106 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim of the study was to compare the consistency of major/minor fetal anomalies detected by second trimester prenatal ultrasound examination with the findings in fetal autopsies following the termination of pregnancy (TOP) in the second trimester. DESIGN: In a 4-year long prospective study, 107 second-trimester TOP was performed due to fetal malformation diagnosed by second trimester-ultrasound examination at a tertiary referral center. Ultrasound findings were compared with fetal autopsy findings. RESULT: Of the 107 cases with major fetal anomalies diagnosed by prenatal ultrasound, 49% had central nervous system anomalies, 23% had kidney and urinary tract anomalies, 11% had congenital heart disease. All of these major anomalies leading to TOP were confirmed by fetal autopsy (100% success rate in major anomalies). Overall success rate in prenatal ultrasound for major and minor anomalies was 77%. The percentage of additional minor anomalies detected in fetal autopsies was 20%. Three percent of the minor anomalies detected by prenatal ultrasonography could not be confirmed during autopsy. Chromosomal anomalies were detected in 9 (16%) out of 57 cases. CONCLUSION: Evaluation of fetal autopsies following TOP enables diagnosis of pathologies undetected by prenatal ultrasound alone, leading to better preconceptional counseling for subsequent pregnancies. |
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Authors:
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Hulya Akgun; Mustafa Basbug; Mahmut Tuncay Ozgun; Ozlem Canoz; Fatma Tokat; Nurcan Murat; Figen Ozturk |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Prenatal diagnosis Volume: 27 ISSN: 0197-3851 ISO Abbreviation: Prenat. Diagn. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-07 Completed Date: 2007-06-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8106540 Medline TA: Prenat Diagn Country: England |
Other Details:
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Languages: eng Pagination: 457-62 Citation Subset: IM |
Affiliation:
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Erciyes University Medical Faculty, Department of Pathology, Kayseri, Turkey. hulyaakgun@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Multiple
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embryology,
ultrasonography* Abortion, Eugenic Adult Autopsy Female Fetus / pathology* Humans Predictive Value of Tests Pregnancy Pregnancy Trimester, Second Prospective Studies Ultrasonography, Prenatal* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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