Document Detail

Correlation between neurotrophic factor expression and outcome of children with severe traumatic brain injury.
MedLine Citation:
PMID:  12845427     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: We evaluated the neurotrophic factors [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glia-derived neurotrophic factor (GDNF)] expression and their association with the severity and outcome of children with traumatic brain injury. DESIGN: Prospective observational clinical study. SETTING: Pediatric intensive care unit. PATIENTS: Fourteen children with severe head injury; 12 controls with obstructive hydrocephalus. MEASUREMENT: Cerebrospinal fluid (CSF) and plasma samples were collected 2 h (T1) and 24 h (T2) after head injury. Neurotrophic factor levels were measured using an immuno-enzymatic assay. MAIN RESULTS: In patients, neurotrophic factor mean levels were significantly different in both CSF and plasma, showing high levels of BDNF compared to NGF and GDNF. Considering T1 and T2 expression, in the CSF the level of NGF increased from 3.5+/-0.4 pg/ml to 48.2+/-11.7 pg/ml ( p<0.001); BDNF decreased from 4854.0+/-1303.7 pg/ml to 593.0+/-114.8 pg/ml ( p<0.001), while GDNF did not undergo significant variations. In plasma, no significant changes were observed. Regarding severity and outcome, BDNF levels showed a sharp peak after head injury, but the only significant association was between NGF expression in the CSF and a good outcome versus a poor outcome ( p=0.007). CONCLUSIONS: The variations in neurotrophic factor levels reflect an endogenous attempt at neuroprotection against biochemical and molecular changes after traumatic head injury. BDNF represents an early marker of brain injury, while NGF expression in the CSF was indicative of a good outcome and the role of this neurotrophin in the treatment of children with severe head injury may be hypothesized.
Antonio Chiaretti; Marco Piastra; Giancarlo Polidori; Concezio Di Rocco; Elena Caresta; Alessia Antonelli; Tiziana Amendola; Luigi Aloe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-07-05
Journal Detail:
Title:  Intensive care medicine     Volume:  29     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-08-07     Completed Date:  2005-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1329-38     Citation Subset:  IM    
Pediatric Intensive Care Unit, Catholic University Medical School, Policlinico Gemelli, Largo Gemelli, 1-00168, Rome, Italy.
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MeSH Terms
Brain Injuries / metabolism*,  pathology
Brain-Derived Neurotrophic Factor / blood,  cerebrospinal fluid
Child, Preschool
Glial Cell Line-Derived Neurotrophic Factor
Nerve Growth Factor / blood,  cerebrospinal fluid
Nerve Growth Factors / blood*,  cerebrospinal fluid*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/GDNF protein, human; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/Nerve Growth Factors; 9061-61-4/Nerve Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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