Document Detail

Correlation between neuroimaging and neurological outcome in periventricular leukomalacia: diagnostic criteria.
MedLine Citation:
PMID:  11380916     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Periventricular leukomalacia (PVL) is the most important factor in cerebral palsy in preterm infants. METHODS: In the present study, we investigated 747 preterm infants of less than 36 weeks gestation who were repeatedly examined by cranial ultrasonography and computed tomography (CT) scanning at around 40 weeks of corrected post-menstrual age. The clinical course of these infants was followed for more than 3 years and they were examined by magnetic resonance imaging (MRI) between 12 and 18 months of age. RESULTS: Single examinations in early infancy were not sufficient to diagnose PVL, but the combination of ultrasonography, CT and MRI examinations allowed the clinical diagnosis of PVL. In preterm infants, clinical PVL could be predicted from cystic PVL and periventricular echogenicity (PVE) 3 or PVE 2 prolonged over 3 weeks on ultrasonography and confirmed by MRI after 11 months of corrected age. CONCLUSIONS: We tried to determine diagnostic criteria for PVL by neuroimaging. Such criteria from neuroimaging for PVL may be useful for determining the exact occurrence rate of and clinical risk factors for PVL.
K Hashimoto; H Hasegawa; Y Kida; Y Takeuchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  43     ISSN:  1328-8067     ISO Abbreviation:  Pediatr Int     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-05-30     Completed Date:  2001-08-30     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  IM    
Division of Neonatal Medicine, Matsudo City Hospital, Matsudo, Chiba, Japan.
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MeSH Terms
Cerebral Palsy / etiology
Child, Preschool
Follow-Up Studies
Infant, Newborn
Infant, Premature
Leukomalacia, Periventricular / complications,  diagnosis*
Magnetic Resonance Imaging
Tomography, X-Ray Computed

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