| Correlation between narrow band imaging and nonneoplastic gastric pathology: a pilot feasibility trial. | |
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MedLine Citation:
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PMID: 18226682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A novel narrow band imaging (NBI) system is able to visualize the mucosal and vascular network in the GI tract. OBJECTIVE: The aim of the current study was to test the feasibility of NBI to predict gastric histologic diagnosis. DESIGN: A pilot feasibility study. SETTING: Veterans Affairs Medical Center. PATIENTS: Forty-seven patients undergoing upper endoscopy for various indications were prospectively enrolled. METHODS: The gastric body and antrum were systematically examined by NBI before targeted biopsies. Images were graded according to the mucosal (ridge/villous and circular) and vascular patterns and correlated with histologic findings in a blinded manner. MAIN OUTCOME MEASUREMENTS: Final histologic diagnosis based on updated Sydney classification system. RESULTS: Overall, 25 patients (53.1%) had a normal biopsy specimen, 13 (27.6%) had non-Helicobacter pylori gastritis, 4 (8.5%) had H pylori gastritis, and 5 (10.6%) had intestinal metaplasia. The sensitivity, specificity, and positive predictive value of a regular mucosal and vascular pattern for the diagnosis of normal mucosa/mild gastritis were 89%, 78%, and 94%, respectively. The sensitivity and specificity of an irregular pattern with decreased density of vessels for the diagnosis of H pylori were 75% and 88%, and that of the ridge/villous pattern for the diagnosis of intestinal metaplasia were 80% and 100%, respectively. LIMITATION: The small number of patients with H pylori and intestinal metaplasia was the main limitation. CONCLUSIONS: This is the first U.S. study of NBI for gastric lesions. NBI may help predict in vivo histologic diagnosis of gastric pathologic conditions with a good degree of accuracy. Future larger studies are needed. |
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Authors:
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Ajay Bansal; Ozlem Ulusarac; Sharad Mathur; Prateek Sharma |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastrointestinal endoscopy Volume: 67 ISSN: 0016-5107 ISO Abbreviation: Gastrointest. Endosc. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-29 Completed Date: 2008-04-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0010505 Medline TA: Gastrointest Endosc Country: United States |
Other Details:
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Languages: eng Pagination: 210-6 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology and Pathology, University of Kansas School of Medicine, Kansas City, Missouri, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Endoscopy, Gastrointestinal / methods* Feasibility Studies Female Gastric Mucosa / blood supply, pathology* Gastritis / microbiology, pathology Helicobacter Infections / pathology Helicobacter pylori Humans Male Middle Aged Pilot Projects Sensitivity and Specificity Stomach Diseases / diagnosis* |
| Comments/Corrections | |
Comment In:
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Gastrointest Endosc. 2008 Feb;67(2):217-8
[PMID:
18226683
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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