Document Detail

Correlation between narrow band imaging and nonneoplastic gastric pathology: a pilot feasibility trial.
MedLine Citation:
PMID:  18226682     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A novel narrow band imaging (NBI) system is able to visualize the mucosal and vascular network in the GI tract. OBJECTIVE: The aim of the current study was to test the feasibility of NBI to predict gastric histologic diagnosis. DESIGN: A pilot feasibility study. SETTING: Veterans Affairs Medical Center. PATIENTS: Forty-seven patients undergoing upper endoscopy for various indications were prospectively enrolled. METHODS: The gastric body and antrum were systematically examined by NBI before targeted biopsies. Images were graded according to the mucosal (ridge/villous and circular) and vascular patterns and correlated with histologic findings in a blinded manner. MAIN OUTCOME MEASUREMENTS: Final histologic diagnosis based on updated Sydney classification system. RESULTS: Overall, 25 patients (53.1%) had a normal biopsy specimen, 13 (27.6%) had non-Helicobacter pylori gastritis, 4 (8.5%) had H pylori gastritis, and 5 (10.6%) had intestinal metaplasia. The sensitivity, specificity, and positive predictive value of a regular mucosal and vascular pattern for the diagnosis of normal mucosa/mild gastritis were 89%, 78%, and 94%, respectively. The sensitivity and specificity of an irregular pattern with decreased density of vessels for the diagnosis of H pylori were 75% and 88%, and that of the ridge/villous pattern for the diagnosis of intestinal metaplasia were 80% and 100%, respectively. LIMITATION: The small number of patients with H pylori and intestinal metaplasia was the main limitation. CONCLUSIONS: This is the first U.S. study of NBI for gastric lesions. NBI may help predict in vivo histologic diagnosis of gastric pathologic conditions with a good degree of accuracy. Future larger studies are needed.
Ajay Bansal; Ozlem Ulusarac; Sharad Mathur; Prateek Sharma
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastrointestinal endoscopy     Volume:  67     ISSN:  0016-5107     ISO Abbreviation:  Gastrointest. Endosc.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-29     Completed Date:  2008-04-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0010505     Medline TA:  Gastrointest Endosc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-6     Citation Subset:  IM    
Department of Gastroenterology and Pathology, University of Kansas School of Medicine, Kansas City, Missouri, USA.
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MeSH Terms
Aged, 80 and over
Endoscopy, Gastrointestinal / methods*
Feasibility Studies
Gastric Mucosa / blood supply,  pathology*
Gastritis / microbiology,  pathology
Helicobacter Infections / pathology
Helicobacter pylori
Middle Aged
Pilot Projects
Sensitivity and Specificity
Stomach Diseases / diagnosis*
Comment In:
Gastrointest Endosc. 2008 Feb;67(2):217-8   [PMID:  18226683 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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