| Correlation between the matrix metalloproteinase-9 activity and chondroitin sulfate concentrations in tear fluid after laser in situ keratomileusis. | |
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MedLine Citation:
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PMID: 20689736 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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AIMS: The aim of the present study was to evaluate the correlation between matrix metalloproteinase-9 (MMP-9) and chondroitin sulfate (CS) concentrations in human tear fluid following laser in situ keratomileusis (LASIK). METHODS: Twelve eyes from six patients who had no ocular complaints except for refractive errors, and who had undergone LASIK, were enrolled in this study. We measured the concentrations of chondroitin 4 sulfate (C4S), chondroitin 6 sulfate (C6S), and MMP-9 activity with an enzyme-linked immunosorbent assay and an enzyme immunocapture activity assay preoperatively and postoperatively on days 1 and 4, week 1, and at 1 and 3 months. RESULTS: Although the preoperative MMP-9 activity and the C4S concentration were highly correlated (r = 0.900; P < 0.001), they were not postoperatively correlated at month 1. Although the preoperative MMP-9 activity and the C6S concentration were highly correlated (r = 0.885; P < 0.001), they were not postoperatively correlated at either week 1 or months 1 and 3. CONCLUSIONS: The correlation appeared to be collapsed by LASIK, and it did not recover to the preoperative score at 3 months post-surgery. Our study indicates that the corneal wound healing was not terminated at 3 months following LASIK. |
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Authors:
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Tetsuya Mutoh; Masaya Nishio; Yukihiro Matsumoto; Kiyomi Arai |
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Publication Detail:
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Type: Journal Article Date: 2010-07-30 |
Journal Detail:
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Title: Clinical ophthalmology (Auckland, N.Z.) Volume: 4 ISSN: 1177-5483 ISO Abbreviation: Clin Ophthalmol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-08-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101321512 Medline TA: Clin Ophthalmol Country: New Zealand |
Other Details:
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Languages: eng Pagination: 823-8 Citation Subset: - |
Affiliation:
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Department of Ophthalmology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan. |
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