Document Detail

Correlation between magnetic resonance imaging findings and histological diagnosis of intrinsic brainstem lesions in adults.
MedLine Citation:
PMID:  22223289     Owner:  NLM     Status:  MEDLINE    
Management of brainstem mass lesions remains a controversial issue, especially when the lesion cannot be excised and when infiltration occurs; moreover, the benefits of a stereotactic procedure are still under debate. In most studies, treatment decisions are based solely on MRI features and do not include a histopathological diagnosis. In the current study, we compared MRI characteristics with histopathological findings of intrinsic brainstem lesions and identified the characteristics associated with the diagnosis of pathologies other than diffuse glioma. From February 1988 through August 2007, 96 brainstem biopsies were performed at the Roger Salengro Hospital in Lille, France, on adult patients with intrinsic brainstem lesions not amenable to excision. Of the 96 patients, 42 were women and 54 were men, with a mean age of 41 years (range, 18-75 years). Data analysis of the MRI findings revealed focal (P < .05) and contrast enhancing lesions (P < .05), and these lesions were significant factors associated with the diagnosis of pathologies other than diffuse glioma. Focal lesions were a significant factor associated with a diagnosis of nontumor lesions (P < .05). In conclusion, the diagnostic effect of stereotactic biopsy on intrinsic brainstem lesions was greater in patients with focal or enhancing lesions shown by MRI, in whom the diagnosis of diffuse glioma was less frequent.
Marcos Dellaretti; Gustavo Touzet; Nicolas Reyns; François Dubois; Sebastião Gusmão; Júlio Leonardo Barbosa Pereira; Serge Blond
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Publication Detail:
Type:  Journal Article     Date:  2012-01-05
Journal Detail:
Title:  Neuro-oncology     Volume:  14     ISSN:  1523-5866     ISO Abbreviation:  Neuro-oncology     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-06-12     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  100887420     Medline TA:  Neuro Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  381-5     Citation Subset:  IM    
Department of Neurosurgery, Santa Casa de Belo Horizonte Av. Francisco Sales, 1111 Bairro Santa Efigĉnia, Belo Horizonte/Brazil, 30150-221.
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MeSH Terms
Brain Stem / pathology
Brain Stem Neoplasms / diagnosis*,  pathology
Glioma / diagnosis*,  pathology
Magnetic Resonance Imaging*
Middle Aged
Stereotaxic Techniques
Young Adult

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