| Correlation between lymphocyte beta 2-adrenoceptor density and mean arterial blood pressure: elevated beta-adrenoceptors in essential hypertension. | |
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MedLine Citation:
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PMID: 6206325 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 41 normotensive volunteers (diastolic pressure, less than 90 mm Hg) the beta 2-adrenoceptor density in lymphocytes was determined by (+/-)-125 iodocyanopindolol (ICYP) binding and compared with that in nine patients with borderline hypertension (diastolic pressure, 90-95 mm Hg) and 45 patients with established essential hypertension (diastolic pressure, greater than 95 mm Hg). The mean number of beta 2-adrenoceptors for controls was 774 +/- 49 (range, 300-1,500) ICYP binding sites/cell. In borderline hypertension it was significantly higher, with 1,037 +/- 22 (range, 950-1,150) sites/cell, and increased further in patients with essential hypertension to 1,424 +/- 72 (range, 700-2,700) sites/cell. The KD values for ICYP, however, were nearly the same in all groups (approximately 50 pM). Calculation of the data of all 95 subjects resulted in a significant positive correlation between beta 2-adrenoceptor density and mean arterial blood pressure (r = 0.637; p less than 0.001). Since the properties of beta 2-adrenoceptors in human lymphocytes resemble those in other tissues, the hypothesis is presented that the increased density of beta 2-adrenoceptors may reflect sympathetic hyperactivity in essential hypertension, which might contribute (perhaps via enhanced release of endogenous noradrenaline through stimulation of presynaptic beta 2-adrenoceptors by adrenaline) to the elevation of blood pressure. |
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Authors:
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O E Brodde; A Prywarra; A Daul; M Anlauf; K D Bock |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 6 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 1984 Jul-Aug |
Date Detail:
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Created Date: 1984-09-24 Completed Date: 1984-09-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 678-82 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Binding, Competitive Blood Pressure* / drug effects Epinephrine / pharmacology Female Humans Hypertension / metabolism, physiopathology* Iodocyanopindolol Isoproterenol / pharmacology Lymphocytes / metabolism* Male Middle Aged Norepinephrine / pharmacology Pindolol / analogs & derivatives, diagnostic use Receptors, Adrenergic, beta / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic, beta; 13523-86-9/Pindolol; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 7683-59-2/Isoproterenol; 83498-72-0/Iodocyanopindolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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