| Correlation between low CSA plasma concentration and severity of acute GvHD in bone marrow transplantation. | |
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MedLine Citation:
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PMID: 3046689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1982 and 1986 51 patients were treated with ciclosporin a (CSA) to prevent graft versus host disease (GvHD) after bone marrow transplantation (BMT). Major side effects of the drug were tremor, hypertension, hepatotoxicity and nephrotoxicity. Acute GvHD 0 degree to II degree occurred in 80% of our patients, and GvHD III degree and IV degree in 20% despite the use of CSA. Two to four days before the onset of GvHD, CSA serum levels were significantly lower on the average in patients who developed GvHD III degree and IV degree compared to the others. Our data indicate that plasma CSA concentrations higher than 250 ng/ml should be achieved to reduce the severity of GvHD after BMT. |
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Authors:
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H Schmidt; G Ehninger; R Dopfer; M Blaurock; R Naumann; H Einsele; M Haen; K Schüch; K Jaschonek; D Niethammer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blut Volume: 57 ISSN: 0006-5242 ISO Abbreviation: Blut Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-10-24 Completed Date: 1988-10-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0173401 Medline TA: Blut Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 139-42 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine II, Children Hospital, Tübingen, Federal Rep[ublic of Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Bone Marrow Transplantation* Child Cyclosporins / administration & dosage, adverse effects, blood* Drug Administration Schedule Follow-Up Studies Graft vs Host Disease / blood, physiopathology*, prevention & control Humans Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Cyclosporins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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