Document Detail


Correlation between lipoprotein(a) serum concentration and severity of coronary artery stenosis in an Iranian population according to Gensini score.
MedLine Citation:
PMID:  17976374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the correlation between serum lipoprotein(a) concentration and existence as well as severity of coronary atherosclerosis. DESIGN AND METHODS: A cross-sectional study was conducted on 826 patients who underwent angiography through measuring blood sugar, serum lipids, lipoprotein(a) and evaluation of coronary stenosis by Gensini score. RESULTS: Gensini score=6 was considered as a cut-off point for coronary disease and 40 mg/dL was determined as lipoprotein(a) cut-off point. Its higher concentration was significantly more frequent in patients with Gensini score>6 (OR: 2.50, p=0.001), independent of gender, smoking, diabetes mellitus and hyperlipidemia. This finding was significant in patients <55 years old. There was a significant relationship between severity of coronary stenosis and higher concentration of serum lipoprotein(a). CONCLUSION: LP(a) serum concentration is an independent risk factor for coronary atherosclerosis in the Iranian population especially at the ages below 55. Also it demonstrates a direct relationship between severity of coronary atherosclerosis (by Gensini score) and serum LP(a).
Authors:
Mohammad Ali Boroumand; Vahab Rekabi; Gholamreza Davoodi; Alireza Amirzadegan; Soheil Saadat; Seyed Hesameddin Abbasi; Reza Hamidian; Leila Poorgholi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-10-16
Journal Detail:
Title:  Clinical biochemistry     Volume:  41     ISSN:  0009-9120     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Affiliation:
Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran. borumand@sina.tums.ac.ir
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Glucose / analysis
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Comorbidity
Coronary Angiography*
Coronary Artery Disease / blood,  epidemiology*,  pathology,  radiography*
Coronary Stenosis / blood,  epidemiology*,  pathology,  radiography
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Female
Humans
Iran / epidemiology
Lipoprotein(a) / blood*
Male
Middle Aged
Multivariate Analysis
Population Groups
Risk Factors
Severity of Illness Index
Smoking
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoprotein(a)

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