| Correlation between lipoprotein(a) serum concentration and severity of coronary artery stenosis in an Iranian population according to Gensini score. | |
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MedLine Citation:
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PMID: 17976374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the correlation between serum lipoprotein(a) concentration and existence as well as severity of coronary atherosclerosis. DESIGN AND METHODS: A cross-sectional study was conducted on 826 patients who underwent angiography through measuring blood sugar, serum lipids, lipoprotein(a) and evaluation of coronary stenosis by Gensini score. RESULTS: Gensini score=6 was considered as a cut-off point for coronary disease and 40 mg/dL was determined as lipoprotein(a) cut-off point. Its higher concentration was significantly more frequent in patients with Gensini score>6 (OR: 2.50, p=0.001), independent of gender, smoking, diabetes mellitus and hyperlipidemia. This finding was significant in patients <55 years old. There was a significant relationship between severity of coronary stenosis and higher concentration of serum lipoprotein(a). CONCLUSION: LP(a) serum concentration is an independent risk factor for coronary atherosclerosis in the Iranian population especially at the ages below 55. Also it demonstrates a direct relationship between severity of coronary atherosclerosis (by Gensini score) and serum LP(a). |
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Authors:
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Mohammad Ali Boroumand; Vahab Rekabi; Gholamreza Davoodi; Alireza Amirzadegan; Soheil Saadat; Seyed Hesameddin Abbasi; Reza Hamidian; Leila Poorgholi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-16 |
Journal Detail:
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Title: Clinical biochemistry Volume: 41 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-04 Completed Date: 2008-06-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 117-20 Citation Subset: IM |
Affiliation:
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Tehran Heart Center, Medical Sciences/University of Tehran, Tehran, Iran. borumand@sina.tums.ac.ir |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Glucose / analysis Cholesterol, HDL / blood Cholesterol, LDL / blood Comorbidity Coronary Angiography* Coronary Artery Disease / blood, epidemiology*, pathology, radiography* Coronary Stenosis / blood, epidemiology*, pathology, radiography Cross-Sectional Studies Enzyme-Linked Immunosorbent Assay Female Humans Iran / epidemiology Lipoprotein(a) / blood* Male Middle Aged Multivariate Analysis Population Groups Risk Factors Severity of Illness Index Smoking |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Lipoprotein(a) |
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