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Correlation between lipid peroxidation and non-enzymatic antioxidants in pregnancy induced hypertension.
MedLine Citation:
PMID:  23105719     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The present study was designed to evaluate the lipid peroxidation and non-enzymatic antioxidants in pregnancyinduced hypertension (PIH) compared with healthy normal pregnant and non-pregnant as controls. 75 cases were studied of which 25 were normal healthy controls (Group A), 25 healthy pregnant women (Group B) of third trimester and 25 were PIH (Group C) of the same trimester. In PIH, malondialdehyde a lipid peroxidation product was significantly increased as compared to normal pregnant and non-pregnant controls. The nonenzymatic antioxidants like reduced glutathione, Vitamin-E, Vitamin-C and Vitamin-A were significantly decreased in normal pregnants as compared to controls. A further significant decrease was noticed in PIH compared to normal pregnants. A significant negative correlation was detected between lipid peroxidation and non-enzymatic antioxidant levels. Our study clearly indicates a relationship between elevated lipid peroxidation, decreased non-enzymatic antioxidant in PIH. The measurement of non-enzymatic antioxidants in plasma may be useful predictor of the likely development of PIH.
Authors:
Sadanand B Patil; M V Kodliwadmath; Sheela M Kodliwadmath
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Publication Detail:
Type:  Journal Article     Date:  2008-03-06
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  23     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  45-8     Citation Subset:  -    
Affiliation:
Department of Biochemistry, J.N. Medical College, Nehru Nagar, Belgaum, 5900010 Karnataka India.
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