| Correlation between inhibitory effect on platelet aggregation and disposition of sulfinpyrazone and its metabolites in rabbits. Part II: Multiple dose study. | |
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MedLine Citation:
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PMID: 3580509 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a crossover study rabbits were given perorally sulfinpyrazone (SO) and the sulfide metabolite (S) every 24 h for 5 days on separate occasions and inhibition of aggregation was measured. The results showed: the dosage regimen is effective if the minimum effective concentration of S is defined to be between 0.5-1.0 microgram ml-1, and the repeated dosing did not cause changes in disposition kinetics except that the terminal half-life of S was reduced after dosing with S. No significant accumulations in trough concentration and inhibition of aggregation were observed. The results obtained in this study could provide some useful information for design of dosage regimen and blood level monitoring for humans. |
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Authors:
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B S Kuo; W A Ritschel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 8 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 1987 Jan-Feb |
Date Detail:
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Created Date: 1987-06-26 Completed Date: 1987-06-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 11-21 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Male Platelet Aggregation / drug effects* Rabbits Sulfides / metabolism Sulfinpyrazone / administration & dosage, blood, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Sulfides; 57-96-5/Sulfinpyrazone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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