| Correlation between histocompatibility antigens and recurrent aphthous stomatitis in the Brazilian population. | |
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MedLine Citation:
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PMID: 19649495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recurrent aphthous stomatitis is a common oral mucosa disorder that affects 20% of the world's population, characterized by recurring painful ulcers in the mouth. The diagnosis is primarily based on the patient's clinical history. Inheritance may pose as a risk factor for the disease; however, the studies available are inconclusive as to the results attained, and they vary according to the population studied. AIM: to typify class I and class II HLA molecules and to assess how frequent these molecules are present in the Brazilian population with Recurrent Aphthous Stomatitis, compared to healthy controls. MATERIALS AND METHODS: In this prospective, cross-sectional and investigative study, thirty one patients with diagnostic hypothesis of recurrent aphthous stomatitis were seen from February of 2004 to May of 2006. We obtained the DNA from those patients who matched the inclusion criteria and typified their HLA by PCR. RESULTS: In those patients with Recurrent Minor Aphthous Stomatitis we found statistically significant occurrences of HLA-A33 and HLA-B35. CONCLUSION: HLA-A33 and HLA-B35 may be associated with recurrent minor aphthous stomatitis in the Brazilian's population. |
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Authors:
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Niels Salles Willo Wilhelmsen; Raimar Weber; Francisco Monteiro; Jorge Kalil; Ivan Dieb Miziara |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brazilian journal of otorhinolaryngology Volume: 75 ISSN: 1808-8686 ISO Abbreviation: Braz J Otorhinolaryngol Publication Date: 2009 May-Jun |
Date Detail:
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Created Date: 2009-08-03 Completed Date: 2010-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101207337 Medline TA: Braz J Otorhinolaryngol Country: Brazil |
Other Details:
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Languages: eng; por Pagination: 426-31 Citation Subset: IM |
Affiliation:
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Medical School, University of S?o Paulo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Brazil Case-Control Studies Child Cross-Sectional Studies Female Histocompatibility Antigens Class I / genetics* Histocompatibility Antigens Class II / genetics* Humans Male Middle Aged Polymerase Chain Reaction Prospective Studies Recurrence Stomatitis, Aphthous / genetics*, immunology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens Class I; 0/Histocompatibility Antigens Class II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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