| Correlation between hepatitis B viremia and the clinical and histological activity of chronic delta hepatitis. | |
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MedLine Citation:
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PMID: 7997189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To analyze the serological, clinical and histological significance of hepatitis B virus (HBV) replication among a group of patients with chronic delta hepatitis (CDH), we have studied the clinical and the histological activity in 49 patients with CDH. The HBV-DNA was analyzed by dot-blot and polymerase chain reaction (PCR). Concomitant infection with hepatitis C virus (HCV) was analyzed by reverse transcriptase (RT)-PCR, HDV replication by dot-blot, and human immunodeficiency virus (HIV) infection by enzyme-linked immunosorbent assay. The subjects were divided into three groups according to HBV-DNA status: group I: 14 patients HBV-DNA dot-blot positive; group II: 29 patients HBV-DNA positive only by PCR, and group III: 6 patients HBV-DNA negative by dot-blot and PCR. We have found HBV-DNA by dot-blot in 28.5% of patients, and by PCR in 87.7%. Also 22 patients were anti-HCV positive (86.3% had HCV-RNA by RT-PCR). The first group (HBV-DNA dot-blot positive) had significantly higher serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) than those in the second and third groups. Likewise, serum ALT and AST were significantly higher in the second group (HBV-DNA positive by PCR) than in those of the third group. Histological inflammatory activity was significantly higher in the group of patients with HBV-DNA detectable by dot-blot. The prevalence of serum HDV-RNA and IgM anti-HDV were similar in the three groups. These results were similar in the anti-HCV-positive and -negative patients. In conclusion, these data suggest that: (1) persistence of HBV replication is a major determinant of severe liver damage in chronic delta hepatitis, and (2) HCV and HIV infections do not influence the natural history of CDH. |
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Authors:
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J L Lozano; J Crespo; F de la Cruz; F Casafont; M J Lopez-Arias; L Martín-Ramos; F Pons-Romero |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Medical microbiology and immunology Volume: 183 ISSN: 0300-8584 ISO Abbreviation: Med. Microbiol. Immunol. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1995-01-17 Completed Date: 1995-01-17 Revised Date: 2007-02-21 |
Medline Journal Info:
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Nlm Unique ID: 0314524 Medline TA: Med Microbiol Immunol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 159-67 Citation Subset: IM; X |
Affiliation:
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Gastroenterology and Hepatology Unit, University Hospital Marqués de Valdecilla, Faculty of Medicine, Santander, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Base Sequence Chronic Disease DNA Probes DNA, Viral / analysis Female HIV Infections / pathology Hepacivirus / genetics, immunology, physiology Hepatitis B / pathology* Hepatitis B virus / genetics, immunology, physiology Hepatitis C / pathology Hepatitis D / pathology* Hepatitis Delta Virus / genetics, immunology, physiology Humans Immunoblotting Immunoglobulin G / analysis Immunoglobulin M / analysis Male Middle Aged Molecular Sequence Data Polymerase Chain Reaction RNA, Viral / analysis Viremia / pathology* Virus Replication / physiology |
| Chemical | |
Reg. No./Substance:
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0/DNA Probes; 0/DNA, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/RNA, Viral |
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