Document Detail


Correlation between fractional flow reserve and intravascular ultrasound lumen area in intermediate coronary artery stenosis.
MedLine Citation:
PMID:  21646065     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Aims: Fractional flow reserve (FFR) of <0.8 or 0.75 is currently used to guide revascularisation in lesions with intermediate coronary stenosis. We assessed whether there is an intravascular ultrasound (IVUS) measurement that can reliably be used to predict when patients should undergo intervention. Methods and results: The analysis included 92 intermediate lesions (84 patients) located in vessel diameters >2.5 mm. Positive FFR was considered present at <0.8 and 0.75. IVUS minimum lumen area (MLA) was correlated to the FFR findings in intermediate lesions with 40-70% stenosis. The mean FFR value was 0.89±0.08. Twenty-four patients (26.1%) had FFR <0.8; 17 (18.5%) <0.75. Positive correlations between FFR and IVUS measurements included MLA (r = 0.34, p<0.001), minimum lumen diameter (MLD) (r=0.31, p=0.004), lesion length (r=-0.5, p<0.001), and area stenosis (r=-0.31, p=0.01). There was no significant correlation between FFR and quantitative coronary angiography in MLD (r=0.19, p=0.06), diameter stenosis (r=0.08, p=0.4), or lesion length (r=-0.14, p=0.17). A receiver operating characteristic curve identified MLA <2.8 mm2 (sensitivity 79.7%, specificity 80.3%) as the best threshold value for FFR <0.75; and MLA <3.2 mm2 as best for FFR <0.8 (sensitivity 69.2%, specificity 68.3%). Conclusions: Anatomic measurements of intermediate coronary lesions obtained by IVUS show a moderate correlation to FFR values, although they differ according to vessel size. IVUS MLA may be used as an alternative to FFR when assessing the need for intervention in intermediate coronary lesion. Vessel size, however, should always be taken into account.
Authors:
Itsik Ben-Dor; Rebecca Torguson; Michael A Gaglia; Manuel A Gonzalez; Gabriel Maluenda; Anh B Bui; Zhenyi Xue; Lowell F Satler; William O Suddath; Joseph Lindsay; Augusto D Pichard; Ron Waksman
Related Documents :
16621395 - Multidetector row ct angiography of living related renal donors: is there a need for ve...
3071585 - A new accurate and non-invasive screening method for renovascular hypertension: the ren...
3592255 - Microarterial pattern of human kidney.
10533305 - Percutaneous transluminal coronary angioplasty for renovascular hypertension in a child...
5433345 - Apparent recurrence of q fever endocarditis following homograft replacement of aortic v...
8599915 - Carbon-laden macrophages in pleural fluid of crack smokers.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology     Volume:  7     ISSN:  1969-6213     ISO Abbreviation:  EuroIntervention     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101251040     Medline TA:  EuroIntervention     Country:  France    
Other Details:
Languages:  eng     Pagination:  225-33     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Washington Hospital Center, Washington, DC, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical and procedural evaluation of the Nile Croco® dedicated stent for bifurcations: a single ce...
Next Document:  The Angio-Seal™ femoral closure device allows immediate ambulation after coronary angiography and ...