Document Detail

Correlation between the exercise-induced increase in left ventricular filling pressure and the extent of ischemic or infarcted myocardium.
MedLine Citation:
PMID:  8747760     Owner:  NLM     Status:  MEDLINE    
We investigated the correlation between left ventricular filling pressure and the extent of ischemic or infarcted myocardium in 39 patients with coronary artery disease: 25 with angina pectoris (group A) and 14 with old myocardial infarction but without overt transient myocardial ischemia (group B). Hemodynamic parameters were measured at rest and during exercise. The extent and severity scores of ischemia or infarct were calculated using thallium-201 (201Tl) myocardial single-photon emission computed tomography. In group A, the extent and severity scores of ischemia were strongly correlated with pulmonary artery wedge pressure at peak exercise (r = 0.71, p < 0.001, r = 0.62, p < 0.01, respectively). In group B, the extent and severity scores of the infarct were significantly correlated with left ventricular ejection fraction (r = -0.81, p < 0.001, r = -0.77, p < 0.01, respectively), but were not correlated with pulmonary artery wedge pressure. Since no relationship was found between the extent of infarct and left ventricular filling pressure, dynamic exercise appears to elicit a different compensatory mechanisms in nonischemic myocardium for exercise-induced transient ischemia and in noninfarcted myocardium for old infarction. The compensatory mechanism in patients with old myocardial infarction may be affected by ventricular remodeling.
A Ando; M Yokota; T Sobue; Y Nishinaka; M Iwase; H Hayashi; H Saito
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  59     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-09-23     Completed Date:  1996-09-23     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  705-14     Citation Subset:  IM    
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
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MeSH Terms
Exercise Test
Heart / physiopathology,  radionuclide imaging
Middle Aged
Myocardial Infarction / physiopathology*,  radionuclide imaging
Myocardial Ischemia / physiopathology*,  radionuclide imaging
Physical Exertion
Pulmonary Wedge Pressure
Stroke Volume
Supine Position
Thallium Radioisotopes / diagnostic use
Tomography, Emission-Computed, Single-Photon
Ventricular Function, Left*
Ventricular Pressure*
Reg. No./Substance:
0/Thallium Radioisotopes

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