Document Detail


Correlation between enhancement pattern of hepatocellular carcinoma on real-time contrast-enhanced ultrasound and tumour cellular differentiation on histopathology.
MedLine Citation:
PMID:  17005515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to evaluate the correlation between the enhancement pattern of hepatocellular carcinoma (HCC) on contrast-enhanced ultrasound (CEUS) and tumour cellular differentiation on histopathology. 189 HCC lesions in 189 patients were retrospectively evaluated with CEUS and histopathological examination. CEUS was performed with SonoVue and contrast pulse sequencing. Histopathological diagnoses were made according to the Edmonson grading system. Significant differences were shown between the time that the HCC became hypoenhancing or remained echogenic in late phase and tumour cellular differentiation (p = 0.006; p = 0.036), but not with the time of commencement of hyperenhancing or commencement of isoenhancing in arterial phase and portal phase (p = 0.164, p = 0.113; p = 0.186, p = 0.070). The timing of HCC becoming hypoenhancing on CEUS is correlated with tumour cellular differentiation; well differentiated tumours wash out more slowly than poorly differentiated ones.
Authors:
G-J Liu; H-X Xu; M-D Lu; X-Y Xie; Z-F Xu; Y-L Zheng; J-Y Liang
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Publication Detail:
Type:  Journal Article     Date:  2006-09-27
Journal Detail:
Title:  The British journal of radiology     Volume:  80     ISSN:  1748-880X     ISO Abbreviation:  Br J Radiol     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0373125     Medline TA:  Br J Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  321-30     Citation Subset:  AIM; IM    
Affiliation:
Department of Medical Ultrasonics, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Hepatocellular / pathology,  physiopathology,  ultrasonography*
Cell Differentiation / physiology
Female
Humans
Image Enhancement / methods
Image Processing, Computer-Assisted / methods
Liver Neoplasms / pathology,  physiopathology,  ultrasonography*
Male
Middle Aged
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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