Document Detail

Correlation between echocardiographic left ventricular mass index and electrocardiographic variables used in left ventricular hypertrophy criteria in Chinese hypertensive patients.
MedLine Citation:
PMID:  20876051     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: We investigated the association between echocardiographic (Echo) left ventricular mass (LVM) indexed to body surface area (LVM/BSA) or height(2.7) (LVM/H(2.7)) and electrocardiographic (ECG) variables in 546 Chinese hypertensives.
METHODS: The study group was stratified by gender and by BMI into obese (BMI > or =28 kg/m(2)), overweight (BMI > or =24 kg/m(2) and BMI <28 kg/m(2)), and healthy weight (BMI <24 kg/m(2)) subgroups. Cornell voltage, Sokolow-Lyon voltage, maximum R amplitude in V(1)-V(6), Gubner-Ungerleider voltage, and the products of these amplitude variables with QRS duration were measured.
RESULTS: None of the ECG and Echo values showed a statistically significant difference between the obese and overweight subgroup; thus, we used only one cut-off point of BMI at 24 kg/m(2) for stratification of the hypertensive population. Cornell voltage, Cornell product and LVM/BSA were only affected by gender in our study. For hypertensives with BMI > or =24 kg/m(2), Cornell product was correlated with LVM/BSA and LVM/H(2.7) most significantly: correlation coefficients were approximately 0.45 for males and 0.40 for females and the correlation trended to be stronger as LVM/BSA or LVM/H(2.7) increased. However, a few ECG variables showed a weak correlation with LVM/BSA or LVM/H(2.7) in the hypertensives without left ventricular hypertrophy (LVH). A low sensitivity and high specificity of ECG criteria for the detection of LVH were also derived using receiver operating characteristic curves.
CONCLUSIONS: We conclude that Cornell product and Cornell voltage are the most convenient predictors for LVM/BSA with stratification only by gender. They are also the best parameters for predicting LVH in obese and overweight Chinese hypertensives, whereas estimation of LVM/BSA, LVM/H(2.7) by ECG is inaccurate in Chinese hypertensives without LVH. The cut-off point of BMI=24 kg/m(2) is suitable for stratification of body weight in further studies regarding Chinese hypertensives.
Liangdi Xie; Zili Wang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hellenic journal of cardiology : HJC = Hellēnikē kardiologikē epitheōrēsē     Volume:  51     ISSN:  2241-5955     ISO Abbreviation:  Hellenic J Cardiol     Publication Date:    2010 Sep-Oct
Date Detail:
Created Date:  2010-09-29     Completed Date:  2011-01-20     Revised Date:  2013-08-07    
Medline Journal Info:
Nlm Unique ID:  101257381     Medline TA:  Hellenic J Cardiol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  391-401     Citation Subset:  IM    
Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou City, PR China.
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MeSH Terms
Aged, 80 and over
Area Under Curve
Body Height
Body Surface Area
Heart Ventricles / ultrasonography*
Hypertension / epidemiology,  ultrasonography*
Hypertrophy, Left Ventricular / diagnosis*
Middle Aged
Obesity / epidemiology
ROC Curve
Retrospective Studies
Risk Assessment / methods
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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