| Correlation between deficiency of immunoglobulin subclass G3 and Gm allotype. | |
| | |
MedLine Citation:
|
PMID: 3565023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Gm allotypes were investigated in 63 Swedes: 46 females and 17 males, in whom serum IgG3 was below 0.35 g/l. Both monoclonal antibodies and polyclonal antisera were used for the quantification. Concentrations of the other IgG subclasses were within the age-related normal ranges. The distribution of the IgG1 genetic markers G1m(a,x,f) differed markedly from that observed in normal Swedes (p less than 0.001). Thus G1m(a) was present in 60 subjects as compared to an expected 36, and phenotype G1m(-f) in 34 subjects as against an expected 8. The mean IgG3 concentration was numerically lower in the G1m(-f) group than in the G1m(+f) cohort, and individuals with IgG3 levels 0.10 g/l were more frequent in the G1m(-f) group. Among Caucasians, G3mg is in linkage disequilibrium with G1ma and our interpretations is that the haplotype G1ma;ax G2m-n G3mg is markedly increased in individuals with IgG3 deficiency. |
| | |
Authors:
|
R Grubb; T Hallberg; L Hammarström; V A Oxelius; C I Smith; R Söderström; T Söderström |
Related Documents
:
|
21354073 - Laparoscopic management of placenta increta after late first-trimester dilation and eva... 10352393 - Pseudohypoparathyroidism type 1b in pregnancy. 22567503 - Dyspnoea at term in an obese mother. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology Volume: 94 ISSN: 0108-0202 ISO Abbreviation: Acta Pathol Microbiol Immunol Scand C Publication Date: 1986 Oct |
Date Detail:
|
Created Date: 1987-05-06 Completed Date: 1987-05-06 Revised Date: 2009-06-04 |
Medline Journal Info:
|
Nlm Unique ID: 8206624 Medline TA: Acta Pathol Microbiol Immunol Scand C Country: DENMARK |
Other Details:
|
Languages: eng Pagination: 187-91 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Dysgammaglobulinemia
/
blood,
diagnosis Female Humans IgG Deficiency* Immunoglobulin G / analysis* Immunoglobulin Gm Allotypes / analysis* Male Phenotype Sweden |
| Chemical | |
Reg. No./Substance:
|
0/Immunoglobulin G; 0/Immunoglobulin Gm Allotypes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of two agglutination tests for differentiation between coagulase positive and coagulase n...
Next Document: Secretory products from thrombin-stimulated human platelets exert an inhibitory effect on NK-cytotox...