| Correlation between cytokine levels of amniotic fluid and histological chorioamnionitis in preterm delivery. | |
| | |
MedLine Citation:
|
PMID: 9120746 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to investigate the correlation between the cytokine levels in the amniotic fluid (AF) and the histological stage of chorioamnionitis (CAM) in premature labor. AF of 6 cases (7 samples of AF were obtained as one was a twin pregnancy) in whom CAM was diagnosed histologically, and 12 cases without CAM were included in this study. Amniotic fluid was obtained within 24 hours prior to delivery. Cytokine levels (IL-2, -4, -6, TNF-alpha, IFN-gamma) in AF were measured by an ELISA method. Levels of IL-2 and -6 in the CAM-positive group (mean +/-S.E., 52.9 +/- 83.9 pg/ml, and 20,537.9 +/- 8853.7 pg/ml, respectively) were higher than those in the CAM-negative group (i.e. undetectable, and 65.6 +/- 27.5, respectively) with a statistical significance of p < 0.05, p < 0.001, respectively. There was a positive linear relationship between IL-6 levels of AF and the placental histological inflammatory stages of Blanc in the CAM-positive group. From these results it would appear that the IL-6 level in AF is the most sensitive test in the detection of extraamniotic infection or intraamniotic infection in preterm labor with intact membranes and also indicates the severity infection. |
| | |
Authors:
|
H Negishi; H Yamada; M Mikuni; T Kishida; K Okuyama; T Sagawa; S Makinoda; S Fujimoto |
Related Documents
:
|
3004216 - Amniotic fluid collagenase inhibitor: correlation with gestational age and fetal lung m... 843496 - Relationship between fetal urine production and amniotic fluid volume in normal pregnan... 7559126 - Teratogenic effects of amniotic sac puncture: a mouse model. 12221516 - The influence of fetoabdominal tissues on fetal ecgs and mcgs. 9364596 - Oxygen and placental villous development: origins of fetal hypoxia. 19576376 - Abdominal cerclage for the treatment of recurrent cervical insufficiency: laparoscopy o... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of perinatal medicine Volume: 24 ISSN: 0300-5577 ISO Abbreviation: J Perinat Med Publication Date: 1996 |
Date Detail:
|
Created Date: 1997-04-24 Completed Date: 1997-04-24 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 633-9 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Hokkaido University, School of Medicine, Sapporo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amniocentesis Amniotic Fluid / metabolism* Birth Weight C-Reactive Protein / metabolism Chorioamnionitis / diagnosis, pathology* Cytokines / metabolism* Female Fever Humans Infant, Newborn Interferon-gamma / metabolism Interleukin-2 / metabolism Interleukin-4 / metabolism Interleukin-6 / metabolism Leukocyte Count Obstetric Labor, Premature* Placenta / pathology Pregnancy Tumor Necrosis Factor-alpha / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Cytokines; 0/Interleukin-2; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Advantages of prenatal diagnosis and early surgery for congenital cystic disease of the lung.
Next Document: Postpartum recovery after severe pre-eclampsia and HELLP-syndrome.