| Correlation between cortisol levels and myocardial infarction mortality among intensive coronary care unit patients during first seven days in hospital. | |
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MedLine Citation:
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PMID: 15931696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To measure cortisol level, its relationship with myocardial infarction, and to determine the correlation of elevated cortisol levels with the outcome of myocardial infarction. METHODS: This study was designed as a pre and post study. The diagnosis of myocardial infarction was established based on the WHO criteria. The patients were followed for seven days. Blood specimens were collected on day 1, 3, 5 and 7. RESULTS: Thirty six patients with myocardial infarction were studied. Four patients (11.1%) died and 32 patients (88.9%) survived. Nineteen patients (52.7%) had large infarcts and 23 patients (63.9%) had myocardial complications. The deceased patient's cortisol level differed significantly from those tht survived (65.68 + 29.07 vs 21350 + 15.82 microg/dl, p < 0.05). The groups with large infarcts and myocardial infarct complications had higher cortisol levels, but the difference was not significant compared with the group with small infarcts and patients without complications. Six patients (16.6%) who received thrombolytic therapy had significantly lower cortisol levels as compared to patients without thrombolytic therapy. The duration of elevation cortisol elevation in the deceased patient was longer than that among those who survived. Similar findings were also true for those with large infarcts when compared to those with small infarcts, as well as myocardial infarct patients with complications when compared to those without. However, the duration of cortisol elevation was shorter among patients who received thrombolytic therapy. CONCLUSION: Cortisol level can be used as a prognostic marker for myocardial mortality. |
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Authors:
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Imran Nito; Sarwono Waspadji; S Harun; H M S Markum |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Acta medica Indonesiana Volume: 36 ISSN: 0125-9326 ISO Abbreviation: Acta Med Indones Publication Date: 2004 Jan-Mar |
Date Detail:
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Created Date: 2005-06-02 Completed Date: 2005-09-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7901042 Medline TA: Acta Med Indones Country: Indonesia |
Other Details:
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Languages: eng Pagination: 8-14 Citation Subset: IM |
Affiliation:
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Division of Renal-Hypertension, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Aged Biological Markers / blood Coronary Care Units* Female Hospital Mortality Humans Hydrocortisone / blood* Indonesia Male Middle Aged Myocardial Infarction / blood*, complications, drug therapy, mortality* Prognosis Survival Analysis Thrombolytic Therapy Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 50-23-7/Hydrocortisone |
| Comments/Corrections | |
Comment In:
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Acta Med Indones. 2004 Jan-Mar;36(1):1-2
[PMID:
15931694
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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