| Correlation between coronary plaque burden and heart weight. | |
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MedLine Citation:
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PMID: 22922119 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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It is unclear if the extent of coronary atherosclerosis is associated with increase in heart muscle mass. We retrospectively reviewed autopsy reports of sudden coronary deaths occurring in a statewide medical examiner system over a one-year period. Cardiomegaly was assessed by height, and given a score of 0-4 based on amount above the upper limit of normal range. Coronary disease was quantitated as number of epicardial arteries with ≥75% cross sectional luminal narrowing. There were 100 hearts with one-vessel disease, 77 with two-vessel disease, and 59 with three- or four-vessel diseases. The extent of disease was less in women than men (P=0.002). Healed infarcts were present in 21% of women and 36% of men. Cardiomegaly was present in 50% of women and 69% of men. By univariate analysis, in patients without hypertension, cardiomegaly score in the three- or four-vessel disease group was significantly greater than in the one-vessel disease group (P=0.005), as well as the frequency of cardiomegaly (P=0.001). Hearts with myocardial scar had a more frequent cardiomegaly (P=0.0004) and higher cardiomegaly score (P=0.004) than without myocardial scar. Moreover, by multivariate analysis, body mass index (P<0.0001), extent of coronary disease (P=0.02) and healed infarct (P=0.04) were positively associated with cardiomegaly. We conclude that there is a significant correlation between the extent of coronary atherosclerosis and cardiac hypertrophy independent of age and body mass index in sudden coronary deaths as well as healed infarct. These data support a causative association between chronic ischemia and cardiomegaly. |
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Authors:
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Mingchang Zhang; Julia Shields; Yang Zhang; Ling Li; David Fowler; Ziqin Zhao; Allen Burke |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-23 |
Journal Detail:
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Title: Pathology, research and practice Volume: - ISSN: 1618-0631 ISO Abbreviation: Pathol. Res. Pract. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806109 Medline TA: Pathol Res Pract Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier GmbH. All rights reserved. |
Affiliation:
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Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai, China; University of Maryland School of Medicine, Baltimore, MD, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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