Document Detail

Correlation between coronary plaque burden and heart weight.
MedLine Citation:
PMID:  22922119     Owner:  NLM     Status:  Publisher    
It is unclear if the extent of coronary atherosclerosis is associated with increase in heart muscle mass. We retrospectively reviewed autopsy reports of sudden coronary deaths occurring in a statewide medical examiner system over a one-year period. Cardiomegaly was assessed by height, and given a score of 0-4 based on amount above the upper limit of normal range. Coronary disease was quantitated as number of epicardial arteries with ≥75% cross sectional luminal narrowing. There were 100 hearts with one-vessel disease, 77 with two-vessel disease, and 59 with three- or four-vessel diseases. The extent of disease was less in women than men (P=0.002). Healed infarcts were present in 21% of women and 36% of men. Cardiomegaly was present in 50% of women and 69% of men. By univariate analysis, in patients without hypertension, cardiomegaly score in the three- or four-vessel disease group was significantly greater than in the one-vessel disease group (P=0.005), as well as the frequency of cardiomegaly (P=0.001). Hearts with myocardial scar had a more frequent cardiomegaly (P=0.0004) and higher cardiomegaly score (P=0.004) than without myocardial scar. Moreover, by multivariate analysis, body mass index (P<0.0001), extent of coronary disease (P=0.02) and healed infarct (P=0.04) were positively associated with cardiomegaly. We conclude that there is a significant correlation between the extent of coronary atherosclerosis and cardiac hypertrophy independent of age and body mass index in sudden coronary deaths as well as healed infarct. These data support a causative association between chronic ischemia and cardiomegaly.
Mingchang Zhang; Julia Shields; Yang Zhang; Ling Li; David Fowler; Ziqin Zhao; Allen Burke
Related Documents :
8484829 - Prognostic significance of progression of coronary atherosclerosis.
9874049 - Comparison of dipyridamole stress echocardiography and perfusion scintigraphy for cardi...
9179089 - The role of diltiazem in treating hypertension and coronary artery disease: new approac...
3769949 - Complementary role of thallium-201 scintigraphy to predischarge exercise electrocardiog...
7977089 - Prognostic significance of a fixed thallium defect one to six months after onset of acu...
8337999 - Early exercise testing after acute myocardial infarction in the elderly: clinical evalu...
10146579 - The evolution of a clinical database to evaluate the treatment of coronary artery disease.
3281989 - Reconsideration of echocardiographic standards for mitral valve prolapse: lack of assoc...
9654389 - Platelet-activating factor antagonism: a new concept in the management of regional myoc...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-23
Journal Detail:
Title:  Pathology, research and practice     Volume:  -     ISSN:  1618-0631     ISO Abbreviation:  Pathol. Res. Pract.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806109     Medline TA:  Pathol Res Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier GmbH. All rights reserved.
Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai, China; University of Maryland School of Medicine, Baltimore, MD, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multifaceted applications of nanomaterials in cell engineering and therapy.
Next Document:  Ectopic uterine tissue as a chronic pain generator.