| Correlation between coronary perfusion pressure and quantitative ECG waveform measures during resuscitation of prolonged ventricular fibrillation. | |
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MedLine Citation:
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PMID: 22562057 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: The ventricular fibrillation (VF) waveform is dynamic and predicts defibrillation success. Quantitative waveform measures (QWM) quantify these changes. Coronary perfusion pressure (CPP), a surrogate for myocardial perfusion, also predicts defibrillation success. The relationship between QWM and CPP has been preliminarily explored. We sought to further delineate this relationship in our porcine model and to determine if it is different between animals with/without ROSC (return of spontaneous circulation). HYPOTHESIS: : A relationship exists between QWM and CPP that is different between animals with/without ROSC. METHODS: Utilizing a prior experiment in our porcine model of prolonged out-of-hospital VF cardiac arrest, we calculated mean CPP, cumulative dose CPP, and percent recovery of three QWM during resuscitation before the first defibrillation: amplitude spectrum area (AMSA), median slope (MS), and logarithm of the absolute correlations (LAC). A random effects linear regression model with an interaction term CPP*ROSC investigated the association between CPP and percent recovery QWM and how this relationship changes with/without ROSC. RESULTS: For 12 animals, CPP and QWM measures (except LAC) improved during resuscitation. A linear relationship existed between CPP and percent recovery AMSA (coefficient 0.27;95%CI 0.23,0.31;p<0.001) and percent recovery MS (coefficient 0.80;95%CI 0.70,0.90;p<0.001). A linear relationship existed between cumulative dose CPP and percent recovery AMSA (coefficient 2.29;95%CI 2.0,2.56;p<0.001) and percent recovery MS (coefficient 6.68;95%CI 6.09, 7.26;p<0.001). Animals with ROSC had a significantly "steeper" dose-response relationship. CONCLUSIONS: There is a linear relationship between QWM and CPP during chest compressions in our porcine cardiac arrest model that is different between animals with/without ROSC. |
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Authors:
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Joshua C Reynolds; David D Salcido; James J Menegazzi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-5-3 |
Journal Detail:
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Title: Resuscitation Volume: - ISSN: 1873-1570 ISO Abbreviation: - Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-5-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0332173 Medline TA: Resuscitation Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
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Department of Emergency Medicine, University of Pittsburgh, Pittsburgh, PA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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