| Correlation between cognitive impairment and cerebral hemodynamic disturbances on perfusion magnetic resonance imaging in European adults with moyamoya disease. Clinical article. | |
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MedLine Citation:
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PMID: 20469988 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECT: Although cognitive impairment has been reported in adults with moyamoya disease (MMD), its relationship with cerebral hemodynamic disturbances has not been investigated. The aims of the present study were to confirm the presence of dysexecutive cognitive syndrome (DCS) in adults with MMD and to explore the relationship of DCS with frontal lobe perfusion as measured by perfusion MR imaging. METHODS: Cerebral blood volume (CBV) ratio and mean transit time delay were measured in frontal and temporoparietal regions using the cerebellum as a reference region in 10 European adults with MMD. In addition, the authors calculated the cerebrovascular reserve (CVR) using the CBV ratio and the acetazolamide challenge. All patients underwent a standardized neuropsychological assessment test battery. The authors defined DCS as an impairment shown on 3 tests or more of executive function. RESULTS: The authors found DCS in 6 patients. The frontal CVR was lower in patients with DCS than in patients without DCS (mean ± SD: -13.5 ± 13.2% and 20.3 ± 21.3%; p = 0.019, Mann-Whitney U-test). Other parameters of frontal perfusion and temporoparietal CVR were not correlated with DCS. CONCLUSIONS: The authors' findings suggest that DCS is common in European adults with MMD and may be related to frontal perfusion impairment. |
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Authors:
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Lionel Calviere; Isabelle Catalaa; Fabienne Marlats; Alain Viguier; Fabrice Bonneville; Christophe Cognard; Vincent Larrue |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurosurgery Volume: 113 ISSN: 1933-0693 ISO Abbreviation: J. Neurosurg. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0253357 Medline TA: J Neurosurg Country: United States |
Other Details:
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Languages: eng Pagination: 753-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, University of Toulouse, Rangueil Hospital, Toulouse, France. liocalviere@free.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetazolamide
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diagnostic use Adult Aged Anticonvulsants / diagnostic use Cerebrovascular Circulation / physiology* Cognition Disorders / etiology, psychology* Executive Function / physiology Female Frontal Lobe / blood supply Humans Magnetic Resonance Imaging Male Middle Aged Moyamoya Disease / physiopathology*, psychology* Neuropsychological Tests |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 59-66-5/Acetazolamide |
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