| Correlation between cell cycle regulators and the immortalization and transformation of human breast epithelial cell lines. | |
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MedLine Citation:
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PMID: 9625804 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular proliferation, essential for normal development, may result in neoplastic growth when the cell cycle clock is disrupted. In order to determine whether the protein expression of cell cycle regulators differs among normal, immortalized non-tumorigenic and malignant human breast epithelial cells (HBECs), we analyzed the protein expression of cyclins D1, D3, A and E, cyclin-dependent kinase (cdk) 4 and c-fos in exponentially growing MCF-10M, MCF-10F, and MCF-7 cells. The tumorigenicity of HBECs in vivo correlated with both cell cycle regulators and early-gene protein expression in vitro. The differential expression of cyclin E- and cyclin A-related proteins and their putative relevance in the tumorigenic properties of HBECs are also discussed. |
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Authors:
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A M Salicioni; I H Russo; J Russo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: International journal of oncology Volume: 13 ISSN: 1019-6439 ISO Abbreviation: Int. J. Oncol. Publication Date: 1998 Jul |
Date Detail:
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Created Date: 1998-08-20 Completed Date: 1998-08-20 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9306042 Medline TA: Int J Oncol Country: GREECE |
Other Details:
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Languages: eng Pagination: 65-71 Citation Subset: IM |
Affiliation:
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Breast Cancer Research Laboratory, Fox Chase Cancer Center, Philadelphia, PA 19111, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast
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cytology* Breast Neoplasms / pathology* Cell Cycle Proteins / physiology* Cell Division Cell Transformation, Neoplastic* Cells, Cultured Epithelial Cells / cytology Female Humans Phenotype Tumor Cells, Cultured |
| Grant Support | |
ID/Acronym/Agency:
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CA64896S/CA/NCI NIH HHS; CA67238/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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