Document Detail

Correlation between the cell cycle in the neurectoderm and differentiation during the early development of Xenopus laevis. 2 Inhibition of DNA synthesis and mitosis during gastrulation.
MedLine Citation:
PMID:  6460598     Owner:  NLM     Status:  MEDLINE    
The hypothesis that cell differentiation during primary induction may be coupled with a 'quantal' cell cycle in the presumptive neurectoderm is considered. Embryos of Xenopus laevis were incubated with fluorodeoxyuridine or mitomycin C during gastrulation or neurulation. Embryos treated during the gastrula stage developed abnormalities of the brain but not of other tissues. This is seen as lending support to the idea that the wave of DNA synthesis and mitosis in the presumptive neurectoderm during gastrulation is an important event in the process of primary induction.
R P Maleyvar; R Lowery
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cytobios     Volume:  32     ISSN:  0011-4529     ISO Abbreviation:  Cytobios     Publication Date:  1981  
Date Detail:
Created Date:  1982-05-27     Completed Date:  1982-05-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0207227     Medline TA:  Cytobios     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  97-105     Citation Subset:  IM    
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MeSH Terms
Cell Cycle / drug effects
Cell Differentiation
DNA Replication / drug effects*
Floxuridine / pharmacology*
Gastrula / drug effects,  physiology*
Mitomycins / pharmacology*
Mitosis / drug effects*
Nervous System / embryology*
Reg. No./Substance:
0/Mitomycins; 50-91-9/Floxuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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